Intake of Vegetables, Fruit, and Fish is Beneficial for Age-Related Macular Degeneration.

Autor: de Koning-Backus APM; Department of Ophthalmology, Erasmus University Medical Center, Rotterdam, The Netherlands; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands; Department of Clinical Epidemiology, University of Amsterdam, Academic Medical Center, Amsterdam, The Netherlands., Buitendijk GHS; Department of Ophthalmology, Erasmus University Medical Center, Rotterdam, The Netherlands; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands., Kiefte-de Jong JC; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands; Leiden University College The Hague, The Hague, The Netherlands., Colijn JM; Department of Ophthalmology, Erasmus University Medical Center, Rotterdam, The Netherlands; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands., Hofman A; Department of Ophthalmology, Erasmus University Medical Center, Rotterdam, The Netherlands; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA., Vingerling JR; Department of Ophthalmology, Erasmus University Medical Center, Rotterdam, The Netherlands; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands., Haverkort EB; Department of Clinical Epidemiology, University of Amsterdam, Academic Medical Center, Amsterdam, The Netherlands; Research Group Innovation in Preventive Care, Research Centre for Innovations in Health Care, University of Applied Sciences Utrecht, Utrecht, The Netherlands., Franco OH; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands., Klaver CCW; Department of Ophthalmology, Erasmus University Medical Center, Rotterdam, The Netherlands; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands; Department of Ophthalmology, Radboud University Medical Center, Nijmegen, The Netherlands. Electronic address: c.c.w.klaver@erasmusmc.nl.
Jazyk: angličtina
Zdroj: American journal of ophthalmology [Am J Ophthalmol] 2019 Feb; Vol. 198, pp. 70-79. Date of Electronic Publication: 2018 Oct 10.
DOI: 10.1016/j.ajo.2018.09.036
Abstrakt: Purpose: What patients should eat to reduce their risk of age-related macular degeneration (AMD) is still unclear. We investigated the effect of a diet recommended by Health Councils on AMD.
Design: Prospective population-based cohort study.
Methods: Four thousand two hundred and two participants from the Rotterdam Study ≥55 years of age who were free of AMD at baseline were included and followed up for 9.1 ± 5.8 years. Incident AMD was graded on fundus photographs. Dietary data were collected using a validated 170-item food frequency questionnaire, and food intakes were categorized into food patterns based on guidelines from Health Councils. Associations with incident AMD were analyzed using Cox proportional hazards models that were adjusted for age, sex, total energy intake, smoking, body mass index, hypertension, education, and income.
Results: Seven hundred fifty-four people developed incident AMD. Intake of the recommended amounts of vegetables (≥200 g/day), fruit (2×/day), and fish (2×/week) were 30.6%, 54.9%, and 12.5%, respectively. In particular, the intake of fish (2×/week) decreased the risk of incident AMD (hazard ratio 0.76 [95% confidence interval 0.60-0.97]). Intake of the recommended amounts of all 3 food groups was only 3.7%, but adherence to this pattern showed a further reduction of the risk of incident AMD (hazard ratio 0.58 [95% confidence interval 0.36-0.93]). Younger age, higher income, and not smoking were associated with this food pattern, but the risk-lowering effects remained significant after additional adjustment for these factors.
Conclusion: A diet of 200 grams per day of vegetables, fruit two times per day, and fish two times per week is associated with a significantly reduced risk of AMD.
(Copyright © 2018 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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