On-chip photodynamic therapy - monitoring cell metabolism using electrochemical microsensors.

Autor: Marzioch J; Laboratory for Sensors, IMTEK - Department of Microsystem Engineering, University of Freiburg, Germany. marzioch@imtek.de., Kieninger J, Weltin A, Flamm H, Aravindalochanan K, Sandvik JA, Pettersen EO, Peng Q, Urban GA
Jazyk: angličtina
Zdroj: Lab on a chip [Lab Chip] 2018 Nov 06; Vol. 18 (22), pp. 3353-3360.
DOI: 10.1039/c8lc00799c
Abstrakt: We introduce a new system which combines metabolic monitoring using electrochemical microsensors with photodynamic therapy on-chip for the first time. Oxygen consumption of T-47D breast cancer cells was measured during therapy with protoporphyrin IX. We determined the efficacy of the therapy and revealed its recovery effects, which underlines the high relevance of continuous monitoring.
Databáze: MEDLINE