| Autor: |
Stojic IM; Department of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, Serbia. drvladakgbg@yahoo.com., Jakovljevic VL, Zivkovic VI, Srejovic IM, Nikolic TR, Jeremic JN, Jeremic NS, Djuric DM, Radonjic KG, Labudovic-Borovic M, Bugarcic ZD, Bogojeski J, Novokmet SS |
| Jazyk: |
angličtina |
| Zdroj: |
General physiology and biophysics [Gen Physiol Biophys] 2018 Sep; Vol. 37 (5), pp. 515-525. |
| DOI: |
10.4149/gpb_2018004 |
| Abstrakt: |
The therapeutic use of cisplatin for the treatment of solid tumours is associated with organ toxicity. Amongst those, the cardiotoxicity is an occasional but very serious and severe side effect. To prevent or reduce these negative effects, many cisplatin analogues have been synthesized and evaluated in terms of being a less toxic and more effective agent. In present study, we examined the effects of cisplatin and its three analogues in the isolated rat heart to determine whether changes in the structure of the platinum complexes (changing of carrier ligands - ethylenediamine; 1,2-diaminocyclohexane; 2,2':6',2''-terpyridine) can influence their cardiotoxic effects. The results of our research indicate that the introduction of aromatic rings in the structure of the platinum complexes has a negative influence on the heart function. Conversely, the other two examined complexes had less negative effects on heart function compared to cisplatin. Our findings may be of interest for a possible synthetic strategy of introducing a carrier ligand that will exert a less cardiotoxic effect. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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