l-selenomethionine supplementation in children and adolescents with autoimmune thyroiditis: A randomized double-blind placebo-controlled clinical trial.

Autor: Kyrgios I; 4th Department of Pediatrics, School of Medicine, Faculty of Health Sciences, Papageorgiou General Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece., Giza S; 4th Department of Pediatrics, School of Medicine, Faculty of Health Sciences, Papageorgiou General Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece., Kotanidou EP; 4th Department of Pediatrics, School of Medicine, Faculty of Health Sciences, Papageorgiou General Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece., Kleisarchaki A; 4th Department of Pediatrics, School of Medicine, Faculty of Health Sciences, Papageorgiou General Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece., Tsinopoulou VR; 4th Department of Pediatrics, School of Medicine, Faculty of Health Sciences, Papageorgiou General Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece., Papadopoulou A; 4th Department of Pediatrics, School of Medicine, Faculty of Health Sciences, Papageorgiou General Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece., Markantonatou AM; Department of Immunology, Papageorgiou General Hospital, Thessaloniki, Greece., Kanellidou E; Department of Immunology, Papageorgiou General Hospital, Thessaloniki, Greece., Giannakou A; Department of Immunology, Papageorgiou General Hospital, Thessaloniki, Greece., Galli-Tsinopoulou A; 4th Department of Pediatrics, School of Medicine, Faculty of Health Sciences, Papageorgiou General Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Jazyk: angličtina
Zdroj: Journal of clinical pharmacy and therapeutics [J Clin Pharm Ther] 2019 Feb; Vol. 44 (1), pp. 102-108. Date of Electronic Publication: 2018 Oct 10.
DOI: 10.1111/jcpt.12765
Abstrakt: What Is Known and Objective: Although a beneficial effect of selenium (Se) administration has been proposed in adults with autoimmune thyroiditis (AT), there is a paucity of similar data in children and adolescents. The purpose of the study was to investigate whether administration of a high dose of organic Se (200 μg daily as l-selenomethionine) has an effect on antithyroid antibody titres in children and adolescents with AT.
Methods: Seventy-one (71) children and adolescents, with a mean age of 11.3 ± 0.3 years (range 4.5-17.8), diagnosed with AT (antibodies against thyroid peroxidase [anti-TPO] and/or thyroglobulin [anti-Tg] ≥60 IU/mL, euthyroidism or treated hypothyroidism and goitre in thyroid gland ultrasonography) were randomized to receive 200 μg l-selenomethionine or placebo daily for 6 months. Blood samples were drawn for measurement of serum fT4, TSH, anti-TPO and anti-Tg levels, and thyroid gland ultrasonography was performed at the entry to the study and after 6 months of treatment.
Results and Discussion: At the end of the study, a statistically significantly higher reduction in anti-Tg levels was observed in the Se group compared to the placebo group (Δ: -70.9 ± 22.1 vs -6.7 ± 60.6 IU/mL, P = 0.021). Although anti-TPO levels were also decreased in the Se group, this change was not statistically different from that of the control group (Δ: -116.2 ± 68.4 vs +262.8 ± 255.5 IU/mL, P = 0.219). No significant difference in thyroid gland volume was observed between the two study groups (P > 0.05).
What Is New and Conclusion: In this original study, organic Se supplementation appears to reduce anti-Tg levels in children and adolescents with AT.
(© 2018 John Wiley & Sons Ltd.)
Databáze: MEDLINE
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