Trypanosoma cruzi seroprevalence among solid organ donors in Ceará State, Brazil.

Autor:	Costa ACD; Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Ceará, Fortaleza, CE, Brasil.; Laboratório de Pesquisa em Doença de Chagas, Universidade Federal do Ceará, Fortaleza, CE, Brasil., Silva Filho JDD; Laboratório de Pesquisa em Doença de Chagas, Universidade Federal do Ceará, Fortaleza, CE, Brasil., Rocha EA; Hospital Universitário Walter Cantídio, Universidade Federal do Ceará, Fortaleza, CE, Brasil., Andrade MC; Programa de Pós-Graduação em Ciências Médicas, Universidade Federal do Ceará, Fortaleza, CE, Brasil., Fidalgo ASOBV; Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Ceará, Fortaleza, CE, Brasil.; Laboratório de Pesquisa em Doença de Chagas, Universidade Federal do Ceará, Fortaleza, CE, Brasil., Almeida ERB; Central de Transplantes, Secretaria de Saúde do Estado do Ceará, Fortaleza, CE, Brasil., Viana CEM; Laboratório de Pesquisa em Doença de Chagas, Universidade Federal do Ceará, Fortaleza, CE, Brasil.; Programa de Pós-Graduação em Patologia, Universidade Federal do Ceará, Fortaleza, CE, Brasil., Freitas EC; Laboratório de Pesquisa em Doença de Chagas, Universidade Federal do Ceará, Fortaleza, CE, Brasil., Coelho ICB; Departamento de Patologia, Universidade Federal do Ceará, Fortaleza, CE, Brasil., Oliveira MF; Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Ceará, Fortaleza, CE, Brasil.; Laboratório de Pesquisa em Doença de Chagas, Universidade Federal do Ceará, Fortaleza, CE, Brasil.
Jazyk:	angličtina
Zdroj:	Revista da Sociedade Brasileira de Medicina Tropical [Rev Soc Bras Med Trop] 2018 Sep-Oct; Vol. 51 (5), pp. 616-621.
DOI:	10.1590/0037-8682-0406-2017
Abstrakt:	Introduction: The transmission of Chagas disease (CD) through blood transfusion, organ transplantation, and oral transmission has gained greater visibility as a result of intensified vector control activities in endemic regions and to control CD in non-endemic regions. In Brazil, Ceará is one of the states that perform the most organ transplants. Therefore, the objective of this study was to assess the prevalence of Trypanosoma cruzi infection in organ donor candidates. Methods: A retrospective analysis was performed on data from potential organ donors at the Center of Transplantation of the State of Ceará from 2010 - 2015. Results: Data from a total of 2,822 potential donors were obtained, of which 1,038 were effective donors and 1,784 were excluded, likely due to lack of family authorization or medical contraindication. The prevalence of T. cruzi infection among these potential donors was 1.3% (n = 29). The majority of infected donors were males aged 41 - 60 years, residing in the interior of the state. Interestingly, 72.4% (n = 21) had positive or inconclusive serology for additional infections, such as cytomegalovirus, hepatitis B and C, and toxoplasmosis. Probability analysis revealed that stroke was the most common cause of death among potential donors with CD. Conclusions: There was a high prevalence of CD and other coinfections among potential solid organ donors in Ceará, and statistical tests have shown that these individuals are at increased risk of stroke when compared to potential non-reactive donors. This work highlights the importance of screening DC infection in potential donors.
Databáze:	MEDLINE
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