IL8 and IL17A polymorphisms associated with multibacillary leprosy and reaction type 1 in a mixed population from southern Brazil.

Autor: Aquino JS; Laboratory of Immunogenetics, Department of Basic Health Sciences, Maringa State University (UEM), Parana, Brazil.; Post Graduation Program of Biosciences and Physiopathology, Department of Clinical Analysis and Biomedicine, Maringa State University (UEM), Parana, Brazil., Ambrosio-Albuquerque EP; Department of Biotechnology, Cell Biology and Genetics, Maringa State University (UEM), Parana, Brazil., Alves HV; Laboratory of Immunogenetics, Department of Basic Health Sciences, Maringa State University (UEM), Parana, Brazil.; Post Graduation Program of Biosciences and Physiopathology, Department of Clinical Analysis and Biomedicine, Maringa State University (UEM), Parana, Brazil., Macedo LC; Laboratory of Immunogenetics, Department of Basic Health Sciences, Maringa State University (UEM), Parana, Brazil.; Post Graduation Program of Biosciences and Physiopathology, Department of Clinical Analysis and Biomedicine, Maringa State University (UEM), Parana, Brazil., Visentainer L; Department of Medicine, Faculty of Medical Sciences, Campinas State University (UNICAMP), São Paulo, Brazil., Sell AM; Post Graduation Program of Biosciences and Physiopathology, Department of Clinical Analysis and Biomedicine, Maringa State University (UEM), Parana, Brazil., Visentainer JEL; Laboratory of Immunogenetics, Department of Basic Health Sciences, Maringa State University (UEM), Parana, Brazil.; Post Graduation Program of Biosciences and Physiopathology, Department of Clinical Analysis and Biomedicine, Maringa State University (UEM), Parana, Brazil.
Jazyk: angličtina
Zdroj: Annals of human genetics [Ann Hum Genet] 2019 Mar; Vol. 83 (2), pp. 110-114. Date of Electronic Publication: 2018 Oct 10.
DOI: 10.1111/ahg.12291
Abstrakt: We evaluated the influence of the IL8 T-738A (nonidentified rs), IL8 T-353A (rs4073), IL17A G197A (rs2275913), and IL17F T7488C (rs763780) single-nucleotide polymorphisms on leprosy. The AA genotype of IL8 T-353A was observed as a risk factor for multibacillary leprosy, regardless of gender and age-of-onset of disease, considering the recessive model (OR, 3.8; 95% CI, 1.1-13.5; P, 0.023). Furthermore, the AA genotype of IL17A G197A was associated with leprosy type 1 reaction (OR, 2.4; 95% CI, 1.1-5.1; P, 0.026) when compared to the group without reaction, which was adjusted for gender and age-of-onset of disease by the model log additive. These results indicate association of IL8 and IL17A polymorphisms with the progression to multibacillary leprosy and with the type 1 reaction, respectively.
(© 2018 John Wiley & Sons Ltd/University College London.)
Databáze: MEDLINE
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