Core-shell microencapsulation of curcumin in PLGA microparticles: programmed for application in ovarian cancer therapy.

Autor: Dwivedi P; a Department of Precision Machinery and Precision Instrumentation , University of Science and Technology of China , Hefei , Anhui , People's Republic of China., Yuan S; a Department of Precision Machinery and Precision Instrumentation , University of Science and Technology of China , Hefei , Anhui , People's Republic of China.; b Department of Biomedical Engineering , The Ohio State University , Columbus , OH , USA., Han S; a Department of Precision Machinery and Precision Instrumentation , University of Science and Technology of China , Hefei , Anhui , People's Republic of China., Mangrio FA; a Department of Precision Machinery and Precision Instrumentation , University of Science and Technology of China , Hefei , Anhui , People's Republic of China., Zhu Z; a Department of Precision Machinery and Precision Instrumentation , University of Science and Technology of China , Hefei , Anhui , People's Republic of China., Lei F; c Department of Modern Mechanics , University of Science and Technology of China , Hefei , Anhui , People's Republic of China., Ming Z; a Department of Precision Machinery and Precision Instrumentation , University of Science and Technology of China , Hefei , Anhui , People's Republic of China., Cheng L; d First affiliated hospital of University of Science and Technology of China , Hefei , Anhui , People's Republic of China., Liu Z; e College of Pharmacy , The Ohio State University , Columbus , OH , USA., Si T; b Department of Biomedical Engineering , The Ohio State University , Columbus , OH , USA.; c Department of Modern Mechanics , University of Science and Technology of China , Hefei , Anhui , People's Republic of China., Xu RX; a Department of Precision Machinery and Precision Instrumentation , University of Science and Technology of China , Hefei , Anhui , People's Republic of China.; b Department of Biomedical Engineering , The Ohio State University , Columbus , OH , USA.
Jazyk: angličtina
Zdroj: Artificial cells, nanomedicine, and biotechnology [Artif Cells Nanomed Biotechnol] 2018; Vol. 46 (sup3), pp. S481-S491. Date of Electronic Publication: 2018 Oct 09.
DOI: 10.1080/21691401.2018.1499664
Abstrakt: In our study, we have established a novel liquid-driven co-flow focusing (LDCF) process to fabricate curcumin (CUR)-loaded poly (lactic-co-glycolic acid) (PLGA) microparticles (CPMs). LDCF-CPMs of size 20.26 ± 2.37 μm have high encapsulation efficiency (>70%) and were intended for application in ovarian cancer by intraperitoneal (IP) administration. LDCF-CPMs have smooth surface with narrow size distribution and a core-shell structured verified by confocal microscopy which can be precisely controlled by changing the flow rates of focusing, outer and inner phases. The LDCF-CPMs reveal the physiochemical stability with sustained release profile corresponding to 95% CUR release over a period of 14 days in an in vitro release medium. Moreover, LDCF-CPMs were testified for cytotoxicity against SKOV-3 ovarian cancer cell lines and peritoneal delivery advantages by animal experiments. The pharmacokinetics of LDCF-CPMs in rats following IP injection shows slow systemic absorption with mean residence time (MRT) of 13.54 h in comparison with 9.82 and 6.74 h for SE-CPMs and free CUR, respectively. In addition, IP delivery of CUR can expose the ovarian tumour to higher concentration for a longer duration by programming the thickness of the shell. The study provides compelling evidence for LDCF-CPMs having high therapeutic opportunity in the treatment of peritoneal cancers, such as ovarian, that reside in the peritoneal cavity.
Databáze: MEDLINE
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