Ion release, antimicrobial and physio-mechanical properties of glass ionomer cement containing micro or nanosized hexametaphosphate, and their effect on enamel demineralization.

Autor: Hosida TY; Department of Pediatric Dentistry and Public Health, School of Dentistry, Araçatuba, São Paulo State University (UNESP), Araçatuba, SP, Brazil., Delbem ACB; Department of Pediatric Dentistry and Public Health, School of Dentistry, Araçatuba, São Paulo State University (UNESP), Araçatuba, SP, Brazil., Morais LA; Department of Pediatric Dentistry and Public Health, School of Dentistry, Araçatuba, São Paulo State University (UNESP), Araçatuba, SP, Brazil., Moraes JCS; Department of Physics and Chemistry, São Paulo State University (UNESP), Ilha Solteira, SP, Brazil., Duque C; Department of Pediatric Dentistry and Public Health, School of Dentistry, Araçatuba, São Paulo State University (UNESP), Araçatuba, SP, Brazil., Souza JAS; Department of Pediatric Dentistry and Public Health, School of Dentistry, Araçatuba, São Paulo State University (UNESP), Araçatuba, SP, Brazil., Pedrini D; Department of Surgery and Integrated Clinic, School of Dentistry, Araçatuba, São Paulo State University (UNESP), Araçatuba, SP, Brazil. denise.pedrini@unesp.br.; Disciplina de Clínica Integrada, Faculdade de Odontologia de Araçatuba - UNESP, Rua José Bonifácio 1193, Araçatuba, SP, 16015-050, Brazil. denise.pedrini@unesp.br.
Jazyk: angličtina
Zdroj: Clinical oral investigations [Clin Oral Investig] 2019 May; Vol. 23 (5), pp. 2345-2354. Date of Electronic Publication: 2018 Oct 08.
DOI: 10.1007/s00784-018-2674-9
Abstrakt: Objectives: To evaluate the effects of hexametaphosphate microparticles (mHMP) or nanoparticles (nHMP) incorporated in glass ionomer cement (GIC) on antimicrobial and physico-mechanical properties, fluoride (F) release, and enamel demineralization.
Material and Methods: HMP solutions were obtained at concentrations of 1, 3, 6, 9, and 12%, for screening of antimicrobial activity. Next, mHMP or nHMP at 6, 9, and 12% were incorporated into a resin-modified GIC and the antibacterial activity was evaluated. The resistance to diametral tensile and compressive strength, surface hardness, and degree of monomer conversion as well as F and HMP releases of GICs were determined. Furthermore, specimens were attached to enamel blocks and submitted to pH-cycling, and mineral loss was determined. Parametric and non-parametric tests were performed, after checking data homoscedasticity (p < 0.05).
Results: HMP solutions at 6, 9, and 12% demonstrated the best antibacterial activity. GIC containing HMP showed better antibacterial effects at 9 and 12% for nHMP. Regarding F and HMP releases, the highest levels of release occurred for groups containing 9 and 12% nHMP. With the increase in HMP concentration, there was lower mineral loss. However, the incorporation of mHMP or nHMP in GIC reduced values of physico-mechanical properties when compared to the control GIC.
Conclusions: nHMP improves antimicrobial activity and fluoride release, and decreases enamel demineralization, but reduces the physico-mechanical properties of GIC.
Clinical Relevance: The association of GIC/HMP could be an alternative material for patients at high risk for dental caries and could be indicated for low-stress regions or provisional restorations.
Databáze: MEDLINE
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