A Family Focused Intervention Influences Hippocampal-Prefrontal Connectivity Through Gains in Self-Regulation.

Autor: Hanson JL; University of Pittsburgh., Gillmore AD; University of Pittsburgh., Yu T; University of Georgia., Holmes CJ; University of Georgia., Hallowell ES; University of Georgia., Barton AW; University of Georgia., Beach SRH; University of Georgia., Galván A; University of California, Los Angeles., MacKillop J; McMaster University., Windle M; Emory University., Chen E; Northwestern University., Miller GE; Northwestern University., Sweet LH; University of Georgia., Brody GH; University of Georgia.
Jazyk: angličtina
Zdroj: Child development [Child Dev] 2019 Jul; Vol. 90 (4), pp. 1389-1401. Date of Electronic Publication: 2018 Oct 08.
DOI: 10.1111/cdev.13154
Abstrakt: The stressors associated with poverty increase the risks for externalizing psychopathology; however, specific patterns of neurobiology and higher self-regulation may buffer against these effects. This study leveraged a randomized control trial, aimed at increasing self-regulation at ~11 years of age. As adults, these same individuals completed functional MRI scanning (M age  = 24.88 years; intervention n = 44; control n = 49). Functional connectivity between the hippocampus and ventromedial prefrontal cortex was examined in relation to the intervention, gains in self-regulation, and present-day externalizing symptoms. Increased connectivity between these brain areas was noted in the intervention group compared to controls. Furthermore, individual gains in self-regulation, instilled by the intervention, statistically explained this brain difference. These results begin to connect neurobiological and psychosocial markers of risk and resiliency.
(© 2018 The Authors. Child Development published by Wiley Periodicals, Inc. on behalf of Society for Research in Child Development.)
Databáze: MEDLINE
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