The relationship between the severity of disability and serum IL-8 in acute ischemic stroke patients.

Autor: Shaheen HA; 1Department of Neurology, Faculty of Medicine, Fayoum University, PO Box: 63514, Fayoum, Egypt., Daker LI; 1Department of Neurology, Faculty of Medicine, Fayoum University, PO Box: 63514, Fayoum, Egypt., Abbass MM; 2Department of Clinical Pathology, Faculty of Medicine, Fayoum University, Fayoum, Egypt., Abd El Fattah AA; 1Department of Neurology, Faculty of Medicine, Fayoum University, PO Box: 63514, Fayoum, Egypt.
Jazyk: angličtina
Zdroj: The Egyptian journal of neurology, psychiatry and neurosurgery [Egypt J Neurol Psychiatr Neurosurg] 2018; Vol. 54 (1), pp. 26. Date of Electronic Publication: 2018 Sep 24.
DOI: 10.1186/s41983-018-0025-z
Abstrakt: Background: Stroke is the third leading cause of death and leading cause of adult disability worldwide. Long-term disability is a significant problem among survivors; post-stroke inflammation is well known to contribute to the expansion of the ischemic lesion resulting in significant morbidity and disability. To study the impact of serum level of IL-8 on severity of disability in patients with acute ischemic stroke in the first 48 h post stroke.
Methods: A cross-sectional case control study was conducted on 44 patients with acute ischemic stroke (in the first 48 h). The patients were subjected to full neurological examination, computed tomography (CT) and magnetic resonance imaging (MRI) of the brain, and assessment of stroke disability using the National Institute of Health Stroke Scale (NIHSS) and modified Rankin Scale (mRS). Measurement of the serum levels of IL-8, erythrocyte sedimentation rate, and C-reactive protein (CRP) was done. Forty-four matched control subjects for their age and sex were included for comparison of serum level of IL-8.
Results: The level of IL-8 was significantly higher in the patients than in the control subjects ( p  < 0.001).There was a statistically significant positive correlation between serum level of IL-8 and disability assessed by NIHSS ( r  = 0.42, p  = 0.004). The patients with moderate disability showed significant higher IL-8 levels than those with minor disability ( p  = 0.02).
Conclusion: The severity of disability in early acute ischemic stroke is highly correlated to the serum level of IL-8.
Competing Interests: Faculty of Medicine, Fayoum University Ethical Committee, had approved the study; written informed consent was obtained from all the patients and control volunteers before study initiation.Not applicableThe authors declare that they have no competing interests. We confirm that we have read the journal’s position on issues involved in ethical publication and affirm that this report is consistent with those guidelines.Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Databáze: MEDLINE
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