Risk analysis and seroprevalence of HEV in people living with HIV/AIDS in Brazil.

Autor: Bezerra LA; Virology Section, Laboratory of Immunopathology Keizo Asami, Federal University of Pernambuco, Recife, Pernambuco, Brazil., de Oliveira-Filho EF; Department of Virology and Experimental Therapy, Aggeu Magalhães Institute, Foundation Oswaldo Cruz, Pernambuco, Brazil., Silva JVJ Júnior; Department of Virology and Experimental Therapy, Aggeu Magalhães Institute, Foundation Oswaldo Cruz, Pernambuco, Brazil; Virology Section, Department of Preventive Veterinary Medicine, Federal University of Santa Maria, Santa Maria, Brazil., Santos Morais VM; Virology Section, Laboratory of Immunopathology Keizo Asami, Federal University of Pernambuco, Recife, Pernambuco, Brazil., Gonçales JP; Virology Section, Laboratory of Immunopathology Keizo Asami, Federal University of Pernambuco, Recife, Pernambuco, Brazil., da Silva DM; Virology Section, Laboratory of Immunopathology Keizo Asami, Federal University of Pernambuco, Recife, Pernambuco, Brazil., Duarte Coêlho MRC; Virology Section, Laboratory of Immunopathology Keizo Asami, Federal University of Pernambuco, Recife, Pernambuco, Brazil; Department of Physiology and Pharmacology, Center of Biosciences, Federal University of Pernambuco, Recife, Pernambuco, Brazil. Electronic address: rcoelholika@gmail.com.
Jazyk: angličtina
Zdroj: Acta tropica [Acta Trop] 2019 Jan; Vol. 189, pp. 65-68. Date of Electronic Publication: 2018 Oct 04.
DOI: 10.1016/j.actatropica.2018.09.026
Abstrakt: Acute Hepatitis E virus (HEV) infection in people living with HIV/AIDS (PLHA) can lead to fulminant hepatic failure, cirrhosis and death. The prevalence of anti-HEV antibodies within this group varies according to the geographical area. However, in South America, studies concerning the detection of HEV in PLHA are rare. Here, we investigated the presence of HEV by serological and molecular detection and evaluated the risk factors associated with infection in PLHA in Pernambuco state, Brazilian Northeast. Serological and molecular detection of HEV was performed in 366 samples of PLHA by ELISA for anti-HEV IgG and RT-PCR, respectively. Anti-HEV IgG prevalence was 4.1% (15/366) and no HEV RNA was detected. Concerning the risk factors, we evaluated, in multivariable analysis, age, years of school, sexual orientation, oral-anal sex, use of injectable drugs and piped water. Among them, only piped water availability could be associated with the HEV infection in PLHA (OR: 0.08; CI 95%: 0.01-0.66; p = 0.0182). This study showed for the first time the association of piped water as protection factor for HEV infection in PLHA. Finally, this is also the first report of HEV seroprevalence in PLHA in the Northeast Brazil.
(Copyright © 2018 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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