[Thrombolysis in pulmonary embolism with high mortality risk: Experience of a cardiology department in sub-Saharan Africa].

Autor: Pessinaba S; Service de cardiologie, CHU Campus Lomé, 03 BP, 30284 Lomé, Togo. Electronic address: spessinaba@yahoo.fr., Atti YDM; Service de cardiologie, CHU Campus Lomé, 03 BP, 30284 Lomé, Togo., Baragou S; Service de cardiologie, CHU Sylvanus, Olympio, Togo., Yayehd K; Service de cardiologie, CHU Campus Lomé, 03 BP, 30284 Lomé, Togo., Pio M; Service de cardiologie, CHU Sylvanus, Olympio, Togo., Afassinou YM; Service de cardiologie, CHU Sylvanus, Olympio, Togo., Kpelafia M; Service de cardiologie, CHU Campus Lomé, 03 BP, 30284 Lomé, Togo., Kaziga WD; Service de cardiologie, CHU Campus Lomé, 03 BP, 30284 Lomé, Togo., Simwetare MF; Service de cardiologie, CHU Campus Lomé, 03 BP, 30284 Lomé, Togo., D'alméida R; Service de cardiologie, CHU Campus Lomé, 03 BP, 30284 Lomé, Togo., Aloumon M; Service de cardiologie, CHU Campus Lomé, 03 BP, 30284 Lomé, Togo., Agbétiafa M; Service de cardiologie, CHU Campus Lomé, 03 BP, 30284 Lomé, Togo., Panchut Nsangou N; Service de cardiologie, CHU Campus Lomé, 03 BP, 30284 Lomé, Togo., Damorou F; Service de cardiologie, CHU Campus Lomé, 03 BP, 30284 Lomé, Togo.
Jazyk: francouzština
Zdroj: Annales de cardiologie et d'angeiologie [Ann Cardiol Angeiol (Paris)] 2019 Feb; Vol. 68 (1), pp. 28-31. Date of Electronic Publication: 2018 Oct 02.
DOI: 10.1016/j.ancard.2018.08.026
Abstrakt: Introduction: High-risk pulmonary embolism (PE) accounts for 5% of total acute PE and is a life-threatening emergency requiring immediate therapeutic management by fibrinolysis. The objective of this work is to describe the experience of thrombolysis in high-risk PE in a cardiology department in Togo.
Patients and Methods: This is an analytical and descriptive study carried out in the cardiology department of the Campus teaching hospital of Lomé over a period of 5 years (August 2012 to July 2017) concerning patients hospitalized for high-risk mortality PE and having undergone streptokinase thrombolysis.
Results: Twenty-eight of the 102 PE were at high risk of mortality (27.5%). They were 9 men and 19 women with an average age of 61.9±14.1 years. The mean systolic blood pressure was 65mmHg and 50% of the patients were placed on dobutamine. Thrombolysis was performed in 22 of the 28 patients (78.6%). Eighteen patients had a short protocol and 4 a long protocol. The mortality rate was 32.1% or 13.6% in the thrombolysis PE versus 100% in the non-thrombolysis PE (P=0.01). Causes of death in thrombolysis were persistent shock (2 cases) at the end of thrombolysis and sudden death occurred 1 month after hospitalization. The average hospital stay was 18.8 days.
Conclusion: The high-risk PE remains today a pathology burdened with heavy mortality. Thrombolysis remains the first treatment to reduce this mortality.
(Copyright © 2018 Elsevier Masson SAS. All rights reserved.)
Databáze: MEDLINE
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