Is there a relationship between body mass index and diabetic retinopathy in type II diabetic patients? A cross sectional study.

Autor: Sarrafan-Chaharsoughi Z; Faculty of Medicine, International Campus of Shahid Sadoghi University of Medical Sciences, Yazd, Iran., Manaviat MR; 2Geriatric Ophthalmology Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran., Namiranian N; 3Yazd diabetes research center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran., Yazdian-Anari P; 4Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran., Rahmanian M; 5Yazd Diabetes Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Jazyk: angličtina
Zdroj: Journal of diabetes and metabolic disorders [J Diabetes Metab Disord] 2018 Apr 28; Vol. 17 (1), pp. 63-69. Date of Electronic Publication: 2018 Apr 28 (Print Publication: 2018).
DOI: 10.1007/s40200-018-0339-5
Abstrakt: Background: Type 2 diabetes mellitus (T2DM) is one of the most important leading causes of disability, premature mortality and Diabetic Retinopathy (DR) that is one of the diabetes-related complications in diabetic patients and the most common cause of vision loss in diabetic patients. The aim of the study was to evaluate the association between DR and body mass index (BMI) in those patients with T2DM.
Methods: This was a central-based, cross-sectional study on 518 diabetic patients. Their medical history and the laboratory data were collected. All the patients received examination of diabetic retinopathy by professional ophthalmologist. Based on their optic fundi findings, they were classified into five groups: No retinopathy, Mild Non-proliferative Diabetic Retinopathy (NPDR), Moderate NPDR, Severe NPDR, Proliferative diabetic retinopathy (PDR). To analysis data SPSS v18 software used. Frequency, percent, mean and standard deviation were used for population description. t test, spearman correlation, partial correlation, analysis of variance (ANOVA) and Chi-square test (χ2) were used for analytic analysis. Multivariate logistic regression was used to estimate the odds ratio.
Results: 518 patients with T2DM 198 male (38%), 320 female (62%) included in this study. The mean age of patients was 61.02 ± 10.18 years. The mean age at onset was 49.06 + 10.52 years and the mean duration of diabetes was 12.09 ± 7.81 years. There was a strong relationship between duration of diabetes and DR ( P  = 0.001). There were strong significant association between the development of DR and Insulin therapy (OR = 5.975). Correlation analysis between Retinopathy and BMI showed that BMI had inverse relationship with DR when BMI considered as a continuous variable ( p -value = 0.009 and correlation coefficient = -0.467).
Conclusion: BMI in diabetic patient is one of the most important clinical parameter for their health and disease progression. We conclude that BMI had inverse relationship with DR when BMI considered as a continuous variable.
Competing Interests: This analytic cross-sectional study was performed in the Yazd Diabetes research center.All the authors consent for publication.The authors declare that they have no conflict of interest.All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, as revised in 2008 [5].Informed consent was obtained from all patients for being included in the study.
Databáze: MEDLINE
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