Association on DISC1 SNPs with schizophrenia risk: A meta-analysis.

Autor: Ma JH; Department of Laboratorial Science and Technology, School of Public Health, Peking University, No. 38 Xue-Yuan Road, Haidian District, Beijing 100191, PR China. Electronic address: mjh@bjmu.edu.cn., Sun XY; Department of Laboratorial Science and Technology, School of Public Health, Peking University, No. 38 Xue-Yuan Road, Haidian District, Beijing 100191, PR China. Electronic address: 1376476693@qq.com., Guo TJ; Graduate School of Peking Union Medical College, Beijing 100730, China. Electronic address: 756210458@qq.com., Barot E; Bioinformatics Center, University of Copenhagen, Copenhagen 2200, Denmark. Electronic address: rdx236@alumni.ku.dk., Wang DF; Chongqing Blood Center, Chongqing, 400015 P.R. China.. Electronic address: wangdongfang@bjmu.edu.cn., Yan LL; Department of Laboratorial Science and Technology, School of Public Health, Peking University, No. 38 Xue-Yuan Road, Haidian District, Beijing 100191, PR China. Electronic address: yll@bjmu.edu.cn., Ni DW; Central Hospital of Fengxian, Shanghai 201499, China., Huang NH; Department of Laboratorial Science and Technology, School of Public Health, Peking University, No. 38 Xue-Yuan Road, Haidian District, Beijing 100191, PR China. Electronic address: hnh@bjmu.edu.cn., Xie Q; Department of Laboratorial Science and Technology, School of Public Health, Peking University, No. 38 Xue-Yuan Road, Haidian District, Beijing 100191, PR China. Electronic address: xieqing94@bjmu.edu.cn., Zeng J; Department of Laboratorial Science and Technology, School of Public Health, Peking University, No. 38 Xue-Yuan Road, Haidian District, Beijing 100191, PR China. Electronic address: zengjing@bjmu.edu.cn., Ou-Yang L; Department of Laboratorial Science and Technology, School of Public Health, Peking University, No. 38 Xue-Yuan Road, Haidian District, Beijing 100191, PR China. Electronic address: ouyangli@bjmu.edu.cn., Liu YQ; Department of Laboratorial Science and Technology, School of Public Health, Peking University, No. 38 Xue-Yuan Road, Haidian District, Beijing 100191, PR China. Electronic address: liuyaqiong@bjmu.edu.cn., Lu QB; Department of Laboratorial Science and Technology, School of Public Health, Peking University, No. 38 Xue-Yuan Road, Haidian District, Beijing 100191, PR China. Electronic address: qingbinlu@bjmu.edu.cn.
Jazyk: angličtina
Zdroj: Psychiatry research [Psychiatry Res] 2018 Dec; Vol. 270, pp. 306-309. Date of Electronic Publication: 2018 Sep 23.
DOI: 10.1016/j.psychres.2018.09.056
Abstrakt: Schizophrenia is a major psychiatric disorder with complex genetic, environmental, and psychological etiologies. Although DISC1 gene has been shown as a risk factor for schizophrenia in some reports, there is a lack of a consensus. We therefore performed separate meta-analyses aiming to assess the associations between DISC1 SNPs and schizophrenia risk. We found that SNP rs821597 is significantly associated with schizophrenia risk in terms of both allelic and genotypic distribution, while SNP rs821616 is associated with schizophrenia in terms of genotypic distribution, especially in cases above 40 years old.
(Copyright © 2018 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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