A control mechanism for intra-mural peri-arterial drainage via astrocytes: How neuronal activity could improve waste clearance from the brain.

Autor: Diem AK; Department of Computational Physiology, Simula Research Laboratory, 1364 Fornebu, Norway.; Computational Engineering and Design, Faculty of Engineering and the Environment, University of Southampton, Southampton Boldrewood Innovation Campus, Southampton, SO16 7QF, United Kingdom., Carare RO; Clinical Neurosciences, Faculty of Medicine, University of Southampton, Southampton General Hospital, Southampton, SO16 6YD, United Kingdom., Weller RO; Neuropathology, Southampton General Hospital, Southampton, SO16 6YD, United Kingdom., Bressloff NW; Computational Engineering and Design, Faculty of Engineering and the Environment, University of Southampton, Southampton Boldrewood Innovation Campus, Southampton, SO16 7QF, United Kingdom.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2018 Oct 04; Vol. 13 (10), pp. e0205276. Date of Electronic Publication: 2018 Oct 04 (Print Publication: 2018).
DOI: 10.1371/journal.pone.0205276
Abstrakt: The mechanisms behind the clearance of soluble waste from deep within the parenchyma of the brain remain unclear. Experimental evidence reveals that one pathway for clearance of waste, termed intra-mural peri-arterial drainage (IPAD), is the rapid drainage of interstitial fluid along basement membranes (BM) of the smooth muscle cells of cerebral arteries; failure of IPAD is closely associated with the pathology of Alzheimer's disease (AD), but its driving mechanism remains unclear. We have previously shown that arterial pulsations generated by the heart beat are not strong enough to drive IPAD. Here we present computational evidence for a mechanism for clearance of waste from the brain that is driven by functional hyperaemia, that is, the dilatation of cerebral arterioles as a consequence of increased nutrient demand from neurons. This mechanism is based on our model for the flow of fluid through the vascular BM. It accounts for clearance rates observed in mouse experiments, and aligns with pathological observations and recommendations to lower the individual risk of AD, such as mental and physical activity. Thus, our neurovascular hypothesis should act as the new working hypothesis for the driving force behind IPAD.
Competing Interests: The authors have declared that no competing interests exist.
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje