The ocular surface in children: A review of current knowledge and meta-analysis of tear film stability and tear secretion in children.

Autor: Chidi-Egboka NC; School of Optometry and Vision Science, UNSW, Sydney, NSW, 2052, Australia., Briggs NE; Stats Central, Markwainwright Analytical Centre, UNSW, Sydney, Australia., Jalbert I; School of Optometry and Vision Science, UNSW, Sydney, NSW, 2052, Australia. Electronic address: i.jalbert@unsw.edu.au., Golebiowski B; School of Optometry and Vision Science, UNSW, Sydney, NSW, 2052, Australia.
Jazyk: angličtina
Zdroj: The ocular surface [Ocul Surf] 2019 Jan; Vol. 17 (1), pp. 28-39. Date of Electronic Publication: 2018 Sep 30.
DOI: 10.1016/j.jtos.2018.09.006
Abstrakt: Purpose: A review of ocular surface and meta-analysis of tear stability (tear break up time, TBUT) and tear secretion (Schirmer test) values in healthy children was conducted.
Methods: Articles published between 1996 and 2017 indexed on MEDLINE, PubMed, Embase, Scopus and Google Scholar were retrieved using defined search terms. Statistical analysis (including sensitivity analysis and meta-regression) was performed.
Results: 23 studies were summarised (5,291 participants; neonates (0-29 days), infants (1 month - 1 year) or children (1-18 years) and a meta-analysis conducted using 15 eligible studies (1,077 participants). The combined mean TBUT in children was 14.64 seconds (s) (95% CI, 11.64, 17.64) and 21.76 s (95% CI, 20.43, 23.09) for sodium fluorescein TBUT and non-invasive TBUT respectively (NIBUT). The combined mean NIBUT was 32.5 s (95% CI, 31.78-33.22) in neonates. The combined mean Schirmer I with and without anesthesia were 16.26 mm/5 min (95% CI, 13.17, 19.36) and 29.30 mm/5 min (95% CI, 27.65, 30.96) in children and 9.36 mm/5 min (95% CI, 6.54, 12.18) and 17.63 mm/5 min (95% CI, 12.03, 23.23) in neonates. Meta-regression showed a significantly lower TBUT in children from studies conducted in Asia (p = 0.004).
Conclusion: There is paucity of data on ocular surface variables in healthy children, making it difficult to draw valid comparisons with adult values.
(Copyright © 2018 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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