Intratumor heterogeneity of HMCN1 mutant alleles associated with poor prognosis in patients with breast cancer.

Autor:	Kikutake C; Medical Institute of Bioregulation, Kyushu University, Fukuoka 812-8582, Japan., Yoshihara M; Medical Institute of Bioregulation, Kyushu University, Fukuoka 812-8582, Japan.; AMED-CREST, Japan Agency for Medical Research and Development, Fukuoka 812-8582, Japan., Sato T; Medical Institute of Bioregulation, Kyushu University, Fukuoka 812-8582, Japan.; AMED-CREST, Japan Agency for Medical Research and Development, Fukuoka 812-8582, Japan., Saito D; Medical Institute of Bioregulation, Kyushu University, Fukuoka 812-8582, Japan.; AMED-CREST, Japan Agency for Medical Research and Development, Fukuoka 812-8582, Japan., Suyama M; Medical Institute of Bioregulation, Kyushu University, Fukuoka 812-8582, Japan.; AMED-CREST, Japan Agency for Medical Research and Development, Fukuoka 812-8582, Japan.
Jazyk:	angličtina
Zdroj:	Oncotarget [Oncotarget] 2018 Sep 07; Vol. 9 (70), pp. 33337-33347. Date of Electronic Publication: 2018 Sep 07 (Print Publication: 2018).
DOI:	10.18632/oncotarget.26071
Abstrakt:	Human breast cancers comprise a complex and highly heterogeneous population of tumor cells. Intratumor heterogeneity is an underlying cause of resistance to effective therapies and disease recurrence. To explore prognostic factors based on intratumor heterogeneity, we analyzed genomic mutations in breast cancer patients registered in The Cancer Genome Atlas. We calculated the variant allele frequency (VAF) at each mutation site and evaluated the associations of VAFs with the prognosis of breast cancer. VAFs of HMCN1 correlated with the prognosis and lymph node status. Although the detailed function of HMCN1 remains unknown, it is located in extracellular matrix and the mutation in the gene might be associated with cancer cell invasion and metastasis. This finding suggests that HMCN1 is a potential metastatic factor and can be a candidate gene for targeted breast cancer therapy. Competing Interests: CONFLICTS OF INTEREST The authors declare they have no competing interests.
Databáze:	MEDLINE
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