Early life disadvantage and adult adiposity: tests of sensitive periods during childhood and behavioural mediation in adulthood.

Autor:	Gilman SE; Social and Behavioral Sciences Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD, USA.; Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA., Huang YT; Institute of Statistical Science, Academia Sinica, Taipei, Taiwan.; Department of Epidemiology.; Department of Biostatistics, Brown School of Public Health, Providence, RI, USA., Jimenez MP; Department of Epidemiology., Agha G; Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY, USA., Chu SH; Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Eaton CB; Department of Epidemiology.; Department of Family Medicine., Goldstein RB; Social and Behavioral Sciences Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD, USA., Kelsey KT; Department of Epidemiology.; Department of Pathology and Laboratory Medicine, Alpert Medical School of Brown University, Providence, RI, USA., Buka SL; Department of Epidemiology., Loucks EB; Department of Epidemiology.; Department of Behavioural and Social Sciences, Brown School of Public Health, Providence, RI, USA.; Department of Medicine, Warren Alpert Medical School of Brown University, Providence, RI, USA.
Jazyk:	angličtina
Zdroj:	International journal of epidemiology [Int J Epidemiol] 2019 Feb 01; Vol. 48 (1), pp. 98-107.
DOI:	10.1093/ije/dyy199
Abstrakt:	Background: Early exposure to socioeconomic disadvantage is associated with obesity. Here we investigated how early, and conducted mediation analyses to identify behavioural factors in adulthood that could explain why. Methods: Among 931 participants in the New England Family Study, we investigated the associations of family socioeconomic disadvantage measured before birth and at age 7 years with the following measures of adiposity in mid-adulthood (mean age = 44.4 years): body mass index (BMI), waist circumference and, among 400 participants, body composition from dual-energy X-ray absorption scans. Results: In linear regressions adjusting for age, sex, race and childhood BMI Z-score, participants in the highest tertile of socioeconomic disadvantage at birth had 2.6 additional BMI units in adulthood [95% confidence interval (CI) = 1.26, 3.96], 5.62 cm waist circumference (95% CI = 2.69, 8.55), 0.73 kg of android fat mass (95% CI = 0.25, 1.21), and 7.65 higher Fat Mass Index (95% CI = 2.22, 13.09). Conditional on disadvantage at birth, socioeconomic disadvantage at age 7 years was not associated with adult adiposity. In mediation analyses, 10-20% of these associations were explained by educational attainment and 5-10% were explained by depressive symptoms. Conclusions: Infancy may be a sensitive period for exposure to socioeconomic disadvantage, as exposure in the earliest years of life confers a larger risk for overall and central adiposity in mid-adulthood than exposure during childhood. Intervention on these two adult risk factors for adiposity would, if all model assumptions were satisfied, only remediate up to one-fifth of the excess adult adiposity among individuals born into socioeconomically disadvantaged households. (Published by Oxford University Press on behalf of the International Epidemiological Association 2018. This work is written by US Government employees and is in the public domain in the US.)
Databáze:	MEDLINE
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