Composite material based on hydroxyapatite and multi-walled carbon nanotubes filled by iron: Preparation, properties and drug release ability.

Autor: Sukhodub LB; Sumy State University, Sumy 40007, Ukraine., Sukhodub LF; Sumy State University, Sumy 40007, Ukraine., Prylutskyy YI; Taras Shevchenko National University of Kyiv, Kyiv 01601, Ukraine., Strutynska NY; Taras Shevchenko National University of Kyiv, Kyiv 01601, Ukraine., Vovchenko LL; Taras Shevchenko National University of Kyiv, Kyiv 01601, Ukraine., Soroca VM; Taras Shevchenko National University of Kyiv, Kyiv 01601, Ukraine., Slobodyanik NS; Taras Shevchenko National University of Kyiv, Kyiv 01601, Ukraine., Tsierkezos NG; Technical University of Ilmenau, Ilmenau 98693, Germany., Ritter U; Technical University of Ilmenau, Ilmenau 98693, Germany. Electronic address: uwe.ritter@tu-ilmenau.de.
Jazyk: angličtina
Zdroj: Materials science & engineering. C, Materials for biological applications [Mater Sci Eng C Mater Biol Appl] 2018 Dec 01; Vol. 93, pp. 606-614. Date of Electronic Publication: 2018 Aug 07.
DOI: 10.1016/j.msec.2018.08.019
Abstrakt: The novel bioactive composite material based on hydroxyapatite and multi-walled carbon nanotubes filled by iron was synthesized by the "wet chemistry" method and characterized in detail by various experimental techniques including the X-ray diffraction, Fourier transform infrared and energy-dispersive X-ray fluorescence spectroscopy, thermogravimetric and differential thermal analysis. The swelling behaviour was quantified by measuring the changes in sample weight as a function of sample immersion time in a phosphate buffered saline (PBS). Bioactivity test was carried out by soaking the samples in PBS. The material composition influence on the model drug release was studied using the high-performance liquid chromatography method. Finally, the mechanical properties (maximal relative deformation, strength and Young's modulus) of the samples under loading were investigated too. The findings clear demonstrate the possibility of application of the created composite material in bioengineering of bone tissue to fill bone defects of various geometries with the function of prolonged release of the drug. It is assumed that this composite material can be used in 3D modeling of areas of bone tissue that have to bear a mechanical load.
(Copyright © 2018 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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