Effect of Preemptive Acetaminophen Administered Within 1 Hour of General Anesthesia on Gastric Residual Volume and pH in Children.

Autor: Burke CN, D'Agostino R, Tait AR, Malviya S, Voepel-Lewis T
Jazyk: angličtina
Zdroj: Journal of perianesthesia nursing : official journal of the American Society of PeriAnesthesia Nurses [J Perianesth Nurs] 2019 Apr; Vol. 34 (2), pp. 297-302. Date of Electronic Publication: 2018 Sep 27.
DOI: 10.1016/j.jopan.2018.05.015
Abstrakt: Purpose: Determine whether preoperative oral acetaminophen increases gastric residual volume and lowers gastric pH.
Design: Prospective, randomized.
Methods: Healthy children, 1 to 14 years, having elective magnetic resonance imaging (MRI) were randomized to oral acetaminophen within 1 hour of induction versus fasting. Gastric volume and pH were measured immediately after intubation. Adverse events were documented from induction through 72 hours post MRI.
Findings: Thirty-seven children completed the study (16 treatment, 21 control). Gastric residual volume between groups was not significantly different. The acetaminophen group had significantly higher pH than control group (1.86 ± 0.42 vs 1.56 ± 0.34; P ≤ .044). Three children in the control and 6 in the treatment group experienced minor adverse events.
Conclusions: Findings suggest administering oral acetaminophen prior to induction of anesthesia is not associated with increased gastric residual volume and increases the gastric pH. Further study is needed to examine outcomes such as aspiration pneumonitis risk.
(Copyright © 2018 American Society of PeriAnesthesia Nurses. Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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