[Histological and clinical characteristics of cases of immunoglobulin G4-related disease in a tertiary hospital, in Cali, Colombia].

Autor:	Silva N; Departamento de Patología, Fundación Valle del Lili, Cali, Colombia., Calvache N; Centro de Investigaciones Clínicas, Fundación Valle del Lili, Cali, Colombia. Electronic address: nata_2794@hotmail.com., Muñoz N; Departamento de Patología, Fundación Valle del Lili, Cali, Colombia., Londoño R; Programa de Medicina, Facultad Ciencias de la Salud, Universidad Icesi, Cali, Colombia., Pérez B; Departamento de Patología, Fundación Valle del Lili, Cali, Colombia., Pacheco R; Centro de Investigaciones Clínicas, Fundación Valle del Lili, Cali, Colombia.
Jazyk:	Spanish; Castilian
Zdroj:	Revista espanola de patologia : publicacion oficial de la Sociedad Espanola de Anatomia Patologica y de la Sociedad Espanola de Citologia [Rev Esp Patol] 2018 Oct - Dec; Vol. 51 (4), pp. 224-231. Date of Electronic Publication: 2018 May 24.
DOI:	10.1016/j.patol.2018.01.004
Abstrakt:	Introduction: Immunoglobulin G4 (IgG4)-related disease has been described in the last decade. It is a fibro-inflammatory condition capable of affecting almost every organ and diagnosis requires both clinical and paraclinical confirmation. We present the largest study to date in Colombia. Objective: To describe the clinical and histopathological characteristics of patients diagnosed with IgG4-related disease at the Fundación Valle del Lili. Methods: Observational-descriptive retrospective study. The clinical and pathological records of patients diagnosed with IgG4-related disease at the Fundación Valle del Lili were reviewed and a descriptive statistical analysis made. Results: From 2013-2016, 16 patients were diagnosed. Median age was 44 years (RIC 30-58) and 10 (62.5%) were women. The most common clinical presentation was a combination of a tumefactive mass, constitutional symptoms and site-related symptoms (43.8%) (n=7). No preference for any organ was seen. Histopathology revealed all cases had dense lymphoplasmacytic infiltrate and storiform-type fibrosis; 75% also had obliterative phlebitis. In all cases≥10 cells/HPF of IgG4+ were found and 81% had a ratio of IgG4+/IgG+>50%. Conclusion: IgG4-related disease appears to be underdiagnosed, probably due to its broad clinical spectrum as well as a low index of awareness among clinicians. We recommend that, when dense lymphoplasmacytic infiltrates, storiform-type fibrosis or obliterative phlebitis are found, immunohistochemistry for IgG and IgG4should be requested. Positive results then must be correlated with complementary studies to confirm the disease. (Copyright © 2018 Sociedad Española de Anatomía Patológica. Publicado por Elsevier España, S.L.U. All rights reserved.)
Databáze:	MEDLINE
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