Cardiac Biomarker Release After Exercise in Healthy Children and Adolescents: A Systematic Review and Meta-Analysis.

Autor: Cirer-Sastre R; National Institute of Physical Education of Catalonia., Legaz-Arrese A; University of Zaragoza., Corbi F; National Institute of Physical Education of Catalonia., George K; Liverpool John Moores University., Nie J; Macao Polytechnic Institute., Carranza-García LE; Universidad Autónoma de Nuevo León., Reverter-Masià J; University of Lleida.
Jazyk: angličtina
Zdroj: Pediatric exercise science [Pediatr Exerc Sci] 2019 Feb 01; Vol. 31 (1), pp. 28-36. Date of Electronic Publication: 2018 Sep 30.
DOI: 10.1123/pes.2018-0058
Abstrakt: Purpose: The authors evaluated the impact of acute exercise and 24-hour recovery on serum concentration of cardiac troponins T and I (cTnT and cTnI) and N-terminal fragment of the prohormone brain natriuretic peptide (NT-proBNP) in healthy children and adolescents. The authors also determined the proportion of participants exceeding the upper reference limits and acute myocardial infarction cutoff for each assay.
Method: Web of Science, SPORTDiscus, MEDLINE, ScienceDirect, and Scopus databases were systematically searched up to November 2017. Studies were screened and quality-assessed; the data was systematically extracted and analyzed.
Results: From 751 studies initially identified, 14 met the inclusion criteria for data extraction. All 3 biomarkers were increased significantly after exercise. A decrease from postexercise to 24 hours was noted in cTnT and cTnI, although this decrease was only statistically significant for cTnT. The upper reference limit was exceeded by 76% of participants for cTnT, a 51% for cTnI, and a 13% for NT-proBNP. Furthermore, the cutoff value for acute myocardial infarction was exceeded by 39% for cTnT and a 11% for cTnI. Postexercise peak values of cTnT were associated with duration and intensity (Q (3)  = 28.3, P < .001) while NT-proBNP peak values were associated with duration (Q (2)  = 11.9, P = .003).
Conclusion: Exercise results in the appearance of elevated levels of cTnT, cTnI, and NT-proBNP in children and adolescents. Postexercise elevations of cTnT and NT-proBNP are associated with exercise duration and intensity.
Databáze: MEDLINE
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