Serum markers and development of delayed neuropsychological sequelae after acute carbon monoxide poisoning: anion gap, lactate, osmolarity, S100B protein, and interleukin-6.

Autor:	Kim H; Department of Emergency Medicine, Ajou University School of Medicine, Suwon, Korea., Choi S; Department of Emergency Medicine, Ajou University School of Medicine, Suwon, Korea.; Center for Safety, Simulation & Advanced Learning Technologies, University of Florida, Gainesville, FL, USA., Park E; Department of Emergency Medicine, Ajou University School of Medicine, Suwon, Korea., Yoon E; Center for Safety, Simulation & Advanced Learning Technologies, University of Florida, Gainesville, FL, USA., Min Y; Department of Emergency Medicine, Ajou University School of Medicine, Suwon, Korea., Lampotang S; Center for Safety, Simulation & Advanced Learning Technologies, University of Florida, Gainesville, FL, USA.
Jazyk:	angličtina
Zdroj:	Clinical and experimental emergency medicine [Clin Exp Emerg Med] 2018 Sep; Vol. 5 (3), pp. 185-191. Date of Electronic Publication: 2018 Sep 30.
DOI:	10.15441/ceem.17.217
Abstrakt:	Objective: Reliable biomarkers of delayed neuropsychological sequelae (DNS) after acute carbon monoxide (CO) poisoning are lacking. This study investigated the associations between potential serum markers and the development of DNS after acute CO poisoning. Methods: Retrospective chart reviews were conducted for patients diagnosed with acute CO poisoning during a 28-month period. The patients were divided into two groups according to the presence or absence of having developed DNS. Multivariate analysis was performed to identify predictors of DNS after CO poisoning. Results: Of a total of 102 patients, 10 (9.8%) developed DNS. The levels of serum osmolarity, S100B protein, and serum lactate, as well as serum anion gap, were statistically significant in univariate analysis. Multiple logistic regression analysis showed that anion gap (adjusted odds ratio [AOR], 1.36; 95% confidence interval [CI], 1.11 to 1.88), serum lactate level (AOR, 1.74; 95% CI, 1.26 to 2.75), and serum S100B protein level ([AOR, 7.02×105; 95% CI, 4.56×102 to 9.00×1010] in model 1, [AOR, 3.69×105; 95% CI, 2.49×102 to 2.71×1011] in model 2) were independently associated with DNS development. Conclusion: Based on our preliminary results, serum lactate level, serum anion gap, and serum S100B protein level in the emergency department could be informative predictors of DNS development in patients with acute CO poisoning. These markers might have the potential to improve early recognition of DNS in patients with acute CO poisoning.
Databáze:	MEDLINE
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