Influence of the surface properties of nanocapsules on their interaction with intestinal barriers.

Autor: Santalices I; Center for Research in Molecular Medicine and Chronic Diseases (CIMUS), Campus Vida, University of Santiago de Compostela, Santiago de Compostela 15782, Spain; Department of Pharmaceutics and Pharmaceutical Technology, School of Pharmacy, Campus Vida, University of Santiago de Compostela, Santiago de Compostela 15782, Spain. Electronic address: irene.santalices@hotmail.es., Torres D; Department of Pharmaceutics and Pharmaceutical Technology, School of Pharmacy, Campus Vida, University of Santiago de Compostela, Santiago de Compostela 15782, Spain. Electronic address: dolores.torres@usc.es., Lozano MV; Cellular Neuroanatomy and Molecular Chemistry of Central Nervous System Group, School of Pharmacy, University of Castilla-La Mancha, Albacete 02071, Spain; Regional Centre of Biomedical Research (CRIB), University of Castilla-La Mancha, Albacete 02071, Spain. Electronic address: mvictoria.lozano@uclm.es., Arroyo-Jiménez MM; Cellular Neuroanatomy and Molecular Chemistry of Central Nervous System Group, School of Pharmacy, University of Castilla-La Mancha, Albacete 02071, Spain; Regional Centre of Biomedical Research (CRIB), University of Castilla-La Mancha, Albacete 02071, Spain. Electronic address: mariamar.arroyo@uclm.es., Alonso MJ; Center for Research in Molecular Medicine and Chronic Diseases (CIMUS), Campus Vida, University of Santiago de Compostela, Santiago de Compostela 15782, Spain; Department of Pharmaceutics and Pharmaceutical Technology, School of Pharmacy, Campus Vida, University of Santiago de Compostela, Santiago de Compostela 15782, Spain. Electronic address: mariaj.alonso@usc.es., Santander-Ortega MJ; Cellular Neuroanatomy and Molecular Chemistry of Central Nervous System Group, School of Pharmacy, University of Castilla-La Mancha, Albacete 02071, Spain; Regional Centre of Biomedical Research (CRIB), University of Castilla-La Mancha, Albacete 02071, Spain. Electronic address: manuel.santander@uclm.es.
Jazyk: angličtina
Zdroj: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V [Eur J Pharm Biopharm] 2018 Dec; Vol. 133, pp. 203-213. Date of Electronic Publication: 2018 Sep 27.
DOI: 10.1016/j.ejpb.2018.09.023
Abstrakt: Despite the convenience of the oral route for drug administration, the existence of different physiological barriers associated with the intestinal tract greatly lowers the bioavailability of many active compounds. We have previously suggested the potential polymeric nanocapsules, consisting of an oily core surrounded by a polymer shell, as oral drug delivery carriers. Here we present a systematic study of the influence of the surface properties of these nanocapsules on their interaction with the intestinal barriers. Two different surfactants, Pluronic®F68 (PF68) and F127 (PF127), and two polymeric shells, chitosan (CS) and polyarginine (PARG) were chosen for the formulation of the nanocapsules. We analyzed nine different combinations of these polymers and surfactants, and studied the effect of each specific combination on their colloidal stability, enzymatic degradation, and mucoadhesion/mucodiffusion. Our results indicate that both, the polymer shell and the surfactants located at the oil/water interface, influence the interaction of the nanocapsules with the intestinal barriers. More interestingly, according to our observations, the shell components of the nanosystems may have either synergic or disruptive effects on their capacity to overcome the intestinal barriers.
(Copyright © 2018. Published by Elsevier B.V.)
Databáze: MEDLINE
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