| Autor: |
Stiller CA, Lennox EL, Wilson LM |
| Jazyk: |
angličtina |
| Zdroj: |
Carcinogenesis [Carcinogenesis] 1987 Jan; Vol. 8 (1), pp. 129-32. |
| DOI: |
10.1093/carcin/8.1.129 |
| Abstrakt: |
In a population-based series of 8045 children with malignant neoplasms in Great Britain, the incidence of septal defects was 0.40%. The high rate of 19% in Down's syndrome children and the overall rate of 0.28% in children without Down's syndrome were both comparable with rates found in previous large prospective studies. The incidence of septal defects in children with Wilms' tumour was 1.82%, greater than 10 times that for non-Down's children with other neoplasms. The presence of this association in Wilms' tumour patients with and without aniridia and the recent finding of a loss of heterozygosity in chromosome 11 in many Wilms' tumours taken from patients without aniridia suggest the possibility of a link between Wilms' tumour, some septal defects and chromosomal abnormalities. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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