Increased risk of incident nasopharyngeal carcinoma with exposure to air pollution.

Autor: Fan HC; Department of Medical Research, Tungs' Taichung Metroharbor Hospital, Taichung, Taiwan.; Department of Pediatrics, Department of Medical Research, Tungs' Taichung Metroharbor Hospital, Taichung, Taiwan.; Department of Rehabilitation, Jen-Teh Junior College of Medicine, Nursing and Management, Miaoli, Taiwan., Chen CY; Department of Public Health, China Medical University, Taichung, Taiwan., Hsu YC; Institute of Biomedical Sciences, Mackay Medical College, New Taipei, Taiwan., Chou RH; Graduate Institute of Biomedical Sciences and Center for Molecular Medicine, China Medical University, Taichung, Taiwan.; Department of Biotechnology, Asia University, Taichung, Taiwan., Teng CJ; Division of Hematology/Medical Oncology, Department of Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.; Department of Life Science, Tunghai University, Taichung, Taiwan.; Department of Medicine, Chung Shan Medical University, Taichung, Taiwan., Chiu CH; Division of Infectious Diseases and Tropical Medicine, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taiwan.; Institute of Clinical Medicine, School of Medicine, National Yang-Ming University, Taiwan., Hsu CY; Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan., Muo CH; Management Office for Health Data, China Medical University Hospital, Taichung, Taiwan., Chang MY; Department of Medical Laboratory Science and Biotechnology, School of Medical and Health Sciences, Fooyin University, Kaohsiung, Taiwan., Chang KH; Department of Medical Research, Tungs' Taichung Metroharbor Hospital, Taichung, Taiwan.; Department of Rehabilitation, Jen-Teh Junior College of Medicine, Nursing and Management, Miaoli, Taiwan.; Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2018 Sep 28; Vol. 13 (9), pp. e0204568. Date of Electronic Publication: 2018 Sep 28 (Print Publication: 2018).
DOI: 10.1371/journal.pone.0204568
Abstrakt: Background: Nasopharyngeal carcinoma (NPC) is a race-specific malignancy. The nasal cavity is the main entry point for air pollutants or poisonous gases into the human body. However, the risk of NPC in populations exposed to air pollution remains unknown.
Methods: We combined data from the Taiwan Air Quality Monitoring Database (TAQMD) and the Longitudinal Health Insurance Database (LHID) to assess the risk of NPC in a population exposed to air pollution.
Results: Multivariate analysis revealed positive trends for the association between the risk of NPC and exposure to air pollution. After adjusting for potential covariates, the risk of developing NPC increased with the increase in nitrogen dioxide (NO2) and fine particulate matter (PM2.5) exposure concentrations from 1.39 to 2.28 and 2.01 to 1.97, respectively, compared to the risks at the lowest concentration levels.
Conclusions: We identified a significant risk of NPC in a population exposed to air pollution. However, this study had several limitations. Moreover, additional experimental and clinical studies on the associations between environmental factors and NPC risk are warranted.
Competing Interests: The authors have declared that no competing interests exist.
Databáze: MEDLINE
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