Cadmium induced damage in Wistar rats, ameliorative potentials of progesterone.

Autor: Alese MO; Department of Anatomy, College of Medicine, Ekiti State University, Ado-Ekiti, Nigeria. Electronic address: margaret.alese@eksu.edu.ng., Agbaje MA; Department of Anatomy, College of Medicine, Ekiti State University, Ado-Ekiti, Nigeria., Alese OO; Department of Physiology, College of Medicine, Ekiti State University, Ado-Ekiti, Nigeria.
Jazyk: angličtina
Zdroj: Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) [J Trace Elem Med Biol] 2018 Dec; Vol. 50, pp. 276-282. Date of Electronic Publication: 2018 Jul 17.
DOI: 10.1016/j.jtemb.2018.07.014
Abstrakt: Asides the increased human exposure to Cadmium containing products; the adverse effects of Cadmium on human health is further exacerbated by its toxicity at low dosage, long biologic half-life and low rate of excretion from the body. This study investigated the protective potential of progesterone on cadmium-induced damage in Wistar rats. Adult male Wistar rats received CdCl 2 once daily for 21 days. Progesterone was given 30 min. after administration of CdCl 2 while 3 other groups were given distilled water, CdCl 2 and progesterone alone. Blood samples were collected from the animals for the determination of liver function and antioxidant status while the liver, kidney, cerebellar and hippocampal tissues were excised and fixed in Neutral buffered formalin for histopathological studies. While Cadmium caused changes in liver function parameters which were indicative of oxidative stress, pre-treatment with progesterone caused restoration to values which were non-significant to the control. Similar findings were made for G6PD, GSH, SOD, CAT and MDA. Histopathology revealed tissue damage in the Cd treated group; this was attenuated by prior treatment with progesterone. Progesterone ameliorated the free radical induced oxidative stress and tissue injury arising from exposure to Cadmium; attention should be given to its antioxidant role in Cadmium toxicity.
(Copyright © 2018 Elsevier GmbH. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: