Two-fold excess of fluoride in the drinking water has no obvious health effects other than dental fluorosis.

Autor: Sezgin BI; Department of Pediatric Dentistry, School of Dentistry, Marmara University, Istanbul, Turkey. Electronic address: batinilgit@gmail.com., Onur ŞG; Department of Pediatric Dentistry, School of Dentistry, Trakya University, Edirne, Turkey. Electronic address: sirin_guner@yahoo.com., Menteş A; Department of Pediatric Dentistry, School of Dentistry, Marmara University, Istanbul, Turkey. Electronic address: alimentes@gmail.com., Okutan AE; Department of Pediatric Dentistry, School of Dentistry, Marmara University, Istanbul, Turkey. Electronic address: alevedaokutan@gmail.com., Haznedaroğlu E; Department of Pediatric Dentistry, School of Dentistry, Marmara University, Istanbul, Turkey. Electronic address: ehaznedaroglu@marmara.edu.tr., Vieira AR; Department of Oral Biology, School of Dental Medicine, University of Pittsburgh, Pittsburgh, USA. Electronic address: alexandre_vieira@pitt.edu.
Jazyk: angličtina
Zdroj: Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) [J Trace Elem Med Biol] 2018 Dec; Vol. 50, pp. 216-222. Date of Electronic Publication: 2018 Jul 11.
DOI: 10.1016/j.jtemb.2018.07.004
Abstrakt: Background: There is concern that fluorides in the drinking water is hazardous to health.
Methods: We conducted an observational study in the village of Hanliyenice (population 280), Turkey, which has 2.5 times higher than optimal levels of fluoride in the drinking water and evaluated all children 7-13 years of age (N = 30). We collected information on dental decay, fluorosis, daily water consumption and diet, child history and her family history of cancer, cardiovascular risks/diseases, and asthma, and obtained a blood sample for extraction of genomic DNA. We genotyped ten single nucleotide polymorphisms in aquaporins.
Results: As expected, a high number of children were dental caries free (19 out of 30) and had fluorosis (25 out of 30). Family history of cancer, cardiovascular events, and asthma was not different from the expected figures based on Turkey. One variant just upstream of AQP5 was associated with being fluorosis free. (G allele of AQP5 rs296763, p = 6.0E -6 ).
Conclusions: Exposure to levels of fluoride twice as high than the optimum in the drinking water increases the prevalence of fluorosis, dramatically decreases dental caries, and does not increase the risk of cancer, cardiovascular events, and asthma.
(Copyright © 2018 Elsevier GmbH. All rights reserved.)
Databáze: MEDLINE
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