Building strength, endurance, and mobility using an astaxanthin formulation with functional training in elderly.

Autor: Liu SZ; Translational Center for Metabolic Imaging Department of Radiology, University of Washington, Seattle, WA., Ali AS; Translational Center for Metabolic Imaging Department of Radiology, University of Washington, Seattle, WA., Campbell MD; Translational Center for Metabolic Imaging Department of Radiology, University of Washington, Seattle, WA., Kilroy K; Translational Center for Metabolic Imaging Department of Radiology, University of Washington, Seattle, WA., Shankland EG; Translational Center for Metabolic Imaging Department of Radiology, University of Washington, Seattle, WA., Roshanravan B; Department of Medicine, University of Washington, Seattle, WA., Marcinek DJ; Translational Center for Metabolic Imaging Department of Radiology, University of Washington, Seattle, WA.; Department of Bioengineering, University of Washington, Seattle, WA.; Department of Pathology, University of Washington, Seattle, WA, USA., Conley KE; Translational Center for Metabolic Imaging Department of Radiology, University of Washington, Seattle, WA.; Department of Physiology and Biophysics, University of Washington, Seattle, WA.; Department of Bioengineering, University of Washington, Seattle, WA.
Jazyk: angličtina
Zdroj: Journal of cachexia, sarcopenia and muscle [J Cachexia Sarcopenia Muscle] 2018 Oct; Vol. 9 (5), pp. 826-833. Date of Electronic Publication: 2018 Sep 26.
DOI: 10.1002/jcsm.12318
Abstrakt: Background: Building both strength and endurance has been a challenge in exercise training in the elderly, but dietary supplements hold promise as agents for improving muscle adaptation. Here, we test a formulation of natural products (AX: astaxanthin, 12 mg and tocotrienol, 10 mg and zinc, 6 mg) with both anti-inflammatory and antioxidant properties in combination with exercise. We conducted a randomized, double-blind, placebo-controlled study of elderly subjects (65-82 years) on a daily oral dose with interval walking exercise on an incline treadmill.
Methods: Forty-two subjects were fed AX or placebo for 4 months and trained 3 months (3×/week for 40-60 min) with increasing intervals of incline walking. Strength was measured as maximal voluntary force (MVC) in ankle dorsiflexion exercise, and tibialis anterior muscle size (cross-sectional area, CSA) was determined from magnetic resonance imaging.
Results: Greater endurance (exercise time in incline walking, >50%) and distance in 6 min walk (>8%) accompanied training in both treatments. Increases in MVC by 14.4% (±6.2%, mean ± SEM, P < 0.02, paired t-test), CSA by 2.7% (±1.0%, P < 0.01), and specific force by 11.6% (MVC/CSA, ±6.0%, P = 0.05) were found with AX treatment, but no change was evident in these properties with placebo treatment (MVC, 2.9% ± 5.6%; CSA, 0.6% ± 1.2%; MVC/CSA, 2.4 ± 5.7%; P > 0.6 for all).
Conclusions: The AX formulation improved muscle strength and CSA in healthy elderly in addition to the elevation in endurance and walking distance found with exercise training alone. Thus, the AX formulation in combination with a functional training programme uniquely improved muscle strength, endurance, and mobility in the elderly.
(© 2018 The Authors. Journal of Cachexia, Sarcopenia and Muscle published by John Wiley & Sons Ltd on behalf of the Society on Sarcopenia, Cachexia and Wasting Disorders.)
Databáze: MEDLINE
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