Changes in aortic pulse wave components, pulse pressure amplification, and hemodynamic parameters of children and adolescents with type 1 diabetes.

Autor:	Duarte SV; Pós-Graduação Ciências Médicas, Faculdade Ciências Médicas-Minas Gerais (FCM-MG), Belo Horizonte, Brazil., de Souza Rajão J; Ambulatório de Endocrinologia do Hospital João Paulo II, Belo Horizonte, Brazil., Pinho JF; Pós-Graduação Ciências Médicas, Faculdade Ciências Médicas-Minas Gerais (FCM-MG), Belo Horizonte, Brazil., Dos Santos LM; Pós-Graduação Ciências Médicas, Faculdade Ciências Médicas-Minas Gerais (FCM-MG), Belo Horizonte, Brazil., Alves-Neves CM; Pós-Graduação Ciências Médicas, Faculdade Ciências Médicas-Minas Gerais (FCM-MG), Belo Horizonte, Brazil., Magalhães GS; Pós-Graduação Ciências Médicas, Faculdade Ciências Médicas-Minas Gerais (FCM-MG), Belo Horizonte, Brazil., Ribeiro-Oliveira A Jr; Serviço de Endocrinologia, Hospital de Clínicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil., Rodrigues-Machado MDG; Pós-Graduação Ciências Médicas, Faculdade Ciências Médicas-Minas Gerais (FCM-MG), Belo Horizonte, Brazil.
Jazyk:	angličtina
Zdroj:	Pediatric diabetes [Pediatr Diabetes] 2019 Mar; Vol. 20 (2), pp. 202-209. Date of Electronic Publication: 2018 Dec 27.
DOI:	10.1111/pedi.12782
Abstrakt:	Background/objective: Type 1 diabetes mellitus (DM1) presents important risk factors for cardiovascular events. Objective: To compare the components of the aortic pulse wave (APW) and the hemodynamic parameters among children and adolescents with DM1 and healthy individuals. Methods: This is a cross-sectional study, with 36 children and adolescents diagnosed with DM1 (11.9 ± 3.2 years) matched by sex and age with the control group (n = 36, 12.4 ± 2.9 years). The components of the APW and the hemodynamic parameters were evaluated non-invasively, using Mobil-O-Graph. Results: On the week of the evaluation, DM1 patients presented glycated hemoglobin (hemoglobin A1C [HbA1c]) of 9.48 ± 2.22% and fasting glycemia of 222.58 ± 93.22 mg/dL. Augmentation index (AIx@75), reflection coefficient, and augmentation pressure (AP) were significantly higher in the DM1 group (29.0 ± 9.7%, 63.0 ± 7.9, and 7.8 ± 2.7 mm Hg, respectively) compared with the control group (20.6 ± 7.9%, 53.4 ± 9.1 and 4.9 ± 2.1 mm Hg, respectively). The systolic volume (52.6 ± 11.9 and 60 ± 12.4 mL) and the cardiac output (4.3 ± 0.5 and 4.6 ± 0.5 L/min) decreased in the DM1 group in relation to the control group. The pulse pressure amplification (PPA) was significantly lower in the DM1 group (1.4 ± 0.15) compared with the control group (1.6 ± 0.17). PPA correlated negatively with total vascular resistance (TVR), AP and reflection coefficient, and positively with cardiac index in both groups. In the DMI group, the AIx@75 correlated negatively with age, height, systolic volume, and PPA, and correlated positively with the TVR and reflection coefficient. Conclusions: These results confirm the presence of arterial stiffness in this population and extend the knowledge, showing, for the first time, the reduction of PPA in the DM1 group. (© 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
Databáze:	MEDLINE
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