| Autor: |
Wu S; School of Materials, University of Manchester, MSS Tower, Manchester, M13 9PL, UK. brian.saunders@manchester.ac.uk., Zhu M, Lian Q, Lu D, Spencer B, Adlam DJ, Hoyland JA, Volk K, Karg M, Saunders BR |
| Jazyk: |
angličtina |
| Zdroj: |
Nanoscale [Nanoscale] 2018 Oct 21; Vol. 10 (39), pp. 18565-18575. Date of Electronic Publication: 2018 Sep 27. |
| DOI: |
10.1039/c8nr07440b |
| Abstrakt: |
The localised surface plasmon resonance (LSPR) of Au nanoparticles (NPs) as well as its interaction with nearby entities provides a wealth of fundamental and practical information at the nanometre scale. A number of studies have investigated core-shell NPs with Au cores and polymer shells that are temperature-responsive. However, there are very few studies of pH-responsive Au-polymer NP shells. Precipitation polymerisation is a scalable method and here we establish such a method to synthesise pH-responsive Au-poly(methyl methacrylate) copolymer core-shell NPs without the need for pre-functionalisation. The comonomers used were methacrylic acid (MAA) or 2-carboxyethyl acrylate (CEA) and the shells were crosslinked with ethylene glycol dimethacrylate. A series of five core-shell systems with collapsed shell thicknesses less than 30 nm are studied. The shell-thicknesses for the CEA-based core-shell NPs are relatively thin (≤5 nm) compared to related Au-polymer core-shell NPs prepared using precipitation polymerisation. The LSPR properties of the core-shell NPs were dependent on the shell thickness and were successfully simulated using finite difference time domain (FDTD) calculations. Two systems are considered further as exemplars. The MAA-based core-shell system with the thickest shell exhibited enhanced colloidal stability to added electrolyte. The CEA-based core-shell dispersion with the thinnest shells displayed reversible pH-triggered aggregation and was cytocompatible for HeLa cells. Proof-of-concept data are presented that demonstrate intracellular pH reporting. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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