Acute toxic effects of ruthenium (II)/amino acid/diphosphine complexes on Swiss mice and zebrafish embryos.
Autor: | Mello-Andrade F; Laboratory of Molecular Genetics and Cytogenetics, Institute of Biological Sciences, Federal University of Goiás, Goiânia, GO, 74690-900, Brazil., Cardoso CG; Department of Morphology, Institute of Biological Sciences, Federal University of Goiás, Goiânia, GO, 74690-900, Brazil., Silva CRE; Laboratory of Radiobiology and Mutagenesis, Institute of Biological Sciences, Federal University of Goiás, Goiânia, GO,74690-900, Brazil., Chen-Chen L; Laboratory of Radiobiology and Mutagenesis, Institute of Biological Sciences, Federal University of Goiás, Goiânia, GO,74690-900, Brazil., Melo-Reis PR; Laboratory of Experimental and Biotechnological Research, Master's Program in Environmental Sciences and Health of School of Medical Sciences, Pharmaceutical and Biomedical, Laboratory, Pontifical Catholic University of Goiás, Goiânia, GO, 74605-010, Brazil., Lima AP; Laboratory of Molecular Genetics and Cytogenetics, Institute of Biological Sciences, Federal University of Goiás, Goiânia, GO, 74690-900, Brazil., Oliveira R; Laboratory of Toxicological Genetics, Department of Genetics and Morphology, Institute of Biological Sciences, University of Brasilia, Brasília, DF, 70910-900, Brazil., Ferraz IBM; Laboratory of Toxicological Genetics, Department of Genetics and Morphology, Institute of Biological Sciences, University of Brasilia, Brasília, DF, 70910-900, Brazil., Grisolia CK; Laboratory of Toxicological Genetics, Department of Genetics and Morphology, Institute of Biological Sciences, University of Brasilia, Brasília, DF, 70910-900, Brazil., Almeida MAP; Coordination of Science and Technology, Federal University of Maranhão, São Luís, MA, 65080-805, Brazil., Batista AA; Department of Chemistry, Federal University of São Carlos, São Carlos, SP, 13565-905, Brazil., Silveira-Lacerda EP; Laboratory of Molecular Genetics and Cytogenetics, Institute of Biological Sciences, Federal University of Goiás, Goiânia, GO, 74690-900, Brazil. Electronic address: silveiralacerda@ufg.br. |
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Jazyk: | angličtina |
Zdroj: | Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2018 Nov; Vol. 107, pp. 1082-1092. Date of Electronic Publication: 2018 Aug 25. |
DOI: | 10.1016/j.biopha.2018.08.051 |
Abstrakt: | Anticancer potential of ruthenium complexes has been widely investigated, but safety evaluation studies are still scarce. Despite of ruthenium-based anticancer agents are known to cause fewer side effects compared to other metal-based drugs, these compounds are not fully free of toxicity, causing mainly nephrotoxicity. Based on the promising results from antitumor activity of the complexes [Ru(L-Met)(bipy)(dppb)]PF (Copyright © 2018 Elsevier Masson SAS. All rights reserved.) |
Databáze: | MEDLINE |
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