Large outbreak of mumps virus genotype G among vaccinated students in Norway, 2015 to 2016.

Autor:	Veneti L; Division for Infection Control and Environmental Health, Norwegian Institute of Public Health, Oslo, Norway.; European Programme for Intervention Epidemiology Training (EPIET), European Centre for Disease Prevention and Control, (ECDC), Stockholm, Sweden., Borgen K; Division for Infection Control and Environmental Health, Norwegian Institute of Public Health, Oslo, Norway., Borge KS; Division for Infection Control and Environmental Health, Norwegian Institute of Public Health, Oslo, Norway., Danis K; European Programme for Intervention Epidemiology Training (EPIET), European Centre for Disease Prevention and Control, (ECDC), Stockholm, Sweden.; Santé publique France, the French national public health agency (SpFrance), Saint-Maurice, France., Greve-Isdahl M; Division for Infection Control and Environmental Health, Norwegian Institute of Public Health, Oslo, Norway., Konsmo K; Division for Infection Control and Environmental Health, Norwegian Institute of Public Health, Oslo, Norway., Njølstad G; Department of Microbiology, Haukeland University Hospital, Bergen, Norway., Nordbø SA; Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway.; Department of Medical Microbiology, St Olavs University Hospital, Trondheim, Norway., Øystese KS; Department of Infectious Disease Control, Municipality of Bergen, Bergen, Norway., Rykkvin R; Division for Infection Control and Environmental Health, Norwegian Institute of Public Health, Oslo, Norway.; European Programme for Public Health Microbiology Training (EUPHEM), European Centre for Disease Prevention and Control, (ECDC), Stockholm, Sweden., Sagvik E; Department of Infectious Disease Control, Municipality of Trondheim, Trondheim, Norway., Riise ØR; Division for Infection Control and Environmental Health, Norwegian Institute of Public Health, Oslo, Norway.
Jazyk:	angličtina
Zdroj:	Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin [Euro Surveill] 2018 Sep; Vol. 23 (38).
DOI:	10.2807/1560-7917.ES.2018.23.38.1700642
Abstrakt:	From 6 September 2015-May 2016, a large mumps outbreak occurred among vaccinated students in Norway. A case was defined as a person presenting with a clinical mumps infection, notified between 1 September 2015 and 30 June 2016. Confirmed cases had positive laboratory confirmation and probable cases had an epidemiological link; PCR-positive specimens were genotyped. A total of 232 cases were notified (230 confirmed) with median age of 23 years (range 4-81) and 61% were male. Of 68 (30%) confirmed cases that were genotyped, 66 were genotype G and associated with the outbreak. Cases that had received two doses of the measles-mumps-rubella (MMR) vaccine had reduced risk of hospitalisation (adjusted relative risk (aRR): 0.14; 95%CI: 0.03-0.57), mumps-related orchitis (aRR: 0.21; 95% CI: 0.08-0.55) and severe outcome (aRR: 0.25; 95% CI: 0.10-0.62) compared with those unvaccinated. A third dose of the vaccine was offered to approximately 1,300 fully vaccinated close contacts and subsequently reported cases decreased. This large outbreak, occurring among predominately vaccinated students, suggests the current genotype A vaccine offers suboptimal protection against mumps genotype G. We recommend maintaining high vaccination coverage and offering the vaccine to all unvaccinated individuals.
Databáze:	MEDLINE
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