| Autor: |
Ishitobi N; Department of Critical Care and Emergency Medicine, Shimane Prefectural Central Hospital, Shimane, Japan., Wan TW; Department of Epidemiology, Genomics and Evolution, International Medical Education and Research Center, Niigata, Japan.; Department of Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University College of Medicine, Taipei, Taiwan., Khokhlova OE; Department of Epidemiology, Genomics and Evolution, International Medical Education and Research Center, Niigata, Japan.; Russia-Japan Center of Microbiology, Metagenomics and Infectious Diseases, Krasnoyarsk State Medical University, Krasnoyarsk, Russia., Teng LJ; Department of Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University College of Medicine, Taipei, Taiwan., Yamamori Y; Department of Critical Care and Emergency Medicine, Shimane Prefectural Central Hospital, Shimane, Japan., Yamamoto T; Department of Epidemiology, Genomics and Evolution, International Medical Education and Research Center, Niigata, Japan. |
| Abstrakt: |
Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) with ST8/SCC mec IV threatens human health. However, its pathogenesis remains unclear. ST8 CA-MRSA (CA-MRSA/J) with SCC mec IVl, which carries the large LPXTG-motif-containing putative adhesin gene, spj, has emerged in Japan. We present the first reported case of death from CA-MRSA/J. The patient was a 64-year-old woman with iliopsoas abscesses complicated by septic pulmonary embolism and multiorgan abscesses. Vancomycin, arbekacin, daptomycin and rifampicin were ineffective. CA-MRSA/J was resistant to erythromycin, clindamycin and antiseptics and was invasive in a HEp-2 cell assay, in contrast to skin-derived villous-adherent CA-MRSA/J. This suggests the strongly invasive pathotype of CA-MRSA/J. |
