The systemic myokine response of decorin, interleukin-6 (IL-6) and interleukin-15 (IL-15) to an acute bout of blood flow restricted exercise.

Autor: Bugera EM; Faculty of Kinesiology and Recreation Management, University of Manitoba, Winnipeg, MB, Canada., Duhamel TA; Faculty of Kinesiology and Recreation Management, University of Manitoba, Winnipeg, MB, Canada.; Centre on Aging, University of Manitoba, Winnipeg, Canada.; Health, Leisure, and Human Performance Research Institute, University of Manitoba, Winnipeg, Canada.; Institute of Cardiovascular Sciences, St. Boniface General Hospital Albrechtsen Research Centre, Winnipeg, Canada., Peeler JD; Centre on Aging, University of Manitoba, Winnipeg, Canada.; Department of Human Anatomy and Cell Sciences, College of Medicine, University of Manitoba, Winnipeg, Canada., Cornish SM; Faculty of Kinesiology and Recreation Management, University of Manitoba, Winnipeg, MB, Canada. Stephen.Cornish@umanitoba.ca.; Centre on Aging, University of Manitoba, Winnipeg, Canada. Stephen.Cornish@umanitoba.ca.; Health, Leisure, and Human Performance Research Institute, University of Manitoba, Winnipeg, Canada. Stephen.Cornish@umanitoba.ca.
Jazyk: angličtina
Zdroj: European journal of applied physiology [Eur J Appl Physiol] 2018 Dec; Vol. 118 (12), pp. 2679-2686. Date of Electronic Publication: 2018 Sep 22.
DOI: 10.1007/s00421-018-3995-8
Abstrakt: Purpose: Blood flow restricted resistance exercise (BFR-RE) is an emerging hypertrophy training modality. A complete profile of its mechanisms of action has yet to be elucidated. Cytokines are universal intercellular messengers. Recent research has implicated certain cytokines (termed "myokines") in skeletal muscle hypertrophy pathways; however, little research has been conducted on the systemic myokine response to BFR-RE as potential hypertrophic biomarkers. Therefore, this project was conducted to determine any differences in the systemic myokine response between BFR-RE and control conditions.
Methods: The appearance of systemic myokines interleukin-6 (IL-6), interleukin-15 (IL-15), and decorin were measured following acute bouts of low-load resistance exercise, BFR-RE, and high-load resistance exercise in physically active young males to determine if BFR-RE modifies the exercise-induced systemic myokine response.
Results: No measurable levels of IL-6 were observed during the project. No significant effects were observed for IL-15. A significant time (11.91% increase pre to post exercise; p < 0.05) but no condition or condition by time effect was observed for decorin.
Conclusion: These findings suggest that BFR-RE does not modify the systemic myokine appearance of IL-6, IL-15, or decorin when compared to control conditions.
Databáze: MEDLINE
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