Synthesis of 28,28,28-trideutero-25-hydroxydihydrotachysterol 2 .

Autor: Sigüeiro R; Department of Organic Chemistry, Laboratorio 'Ignacio Ribas', University of Santiago de Compostela, Avda Ciencias s/n, 15782, Santiago de Compostela, Spain., Loureiro J; Department of Organic Chemistry, Laboratorio 'Ignacio Ribas', University of Santiago de Compostela, Avda Ciencias s/n, 15782, Santiago de Compostela, Spain., González-Berdullas P; Department of Organic Chemistry, Laboratorio 'Ignacio Ribas', University of Santiago de Compostela, Avda Ciencias s/n, 15782, Santiago de Compostela, Spain., Mouriño A; Department of Organic Chemistry, Laboratorio 'Ignacio Ribas', University of Santiago de Compostela, Avda Ciencias s/n, 15782, Santiago de Compostela, Spain., Maestro MA; Department of Chemistry-CICA, Faculty of Sciences, Universty of A Coruña, Campus da Zapateira s/n, 15071 A Coruña, Spain. Electronic address: miguel.maestro@udc.es.
Jazyk: angličtina
Zdroj: The Journal of steroid biochemistry and molecular biology [J Steroid Biochem Mol Biol] 2019 Jan; Vol. 185, pp. 248-250. Date of Electronic Publication: 2018 Sep 19.
DOI: 10.1016/j.jsbmb.2018.09.014
Abstrakt: As part of our program on synthesis of labeled vitamin D metabolites and analogs, we describe here an efficient and versatile synthetic approach to 28,28,28-trideutero- 25-hydroxydihydrotachysterol 2 where isotopic labeling was incorporated stereoselectively in the last step of the synthesis. This deuterated compound will allow the study this analog in vitro or in vivo and to measure AT10-like compounds in serum by LC-MS/MS.
(Copyright © 2018 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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