Periodic limb movements in sleep: Prevalence and associated sleepiness in the Wisconsin Sleep Cohort.

Autor: Leary EB; Stanford University Center for Sleep Sciences and Medicine, Psychiatry and Behavioral Medicine, Stanford University, CA, USA., Moore HE 4th; Stanford University Center for Sleep Sciences and Medicine, Psychiatry and Behavioral Medicine, Stanford University, CA, USA., Schneider LD; Stanford University Center for Sleep Sciences and Medicine, Psychiatry and Behavioral Medicine, Stanford University, CA, USA., Finn LA; School of Medicine and Public Health, Department of Population Health Sciences, University of Wisconsin-Madison, WI, USA., Peppard PE; School of Medicine and Public Health, Department of Population Health Sciences, University of Wisconsin-Madison, WI, USA., Mignot E; Stanford University Center for Sleep Sciences and Medicine, Psychiatry and Behavioral Medicine, Stanford University, CA, USA. Electronic address: mignot@stanford.edu.
Jazyk: angličtina
Zdroj: Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology [Clin Neurophysiol] 2018 Nov; Vol. 129 (11), pp. 2306-2314. Date of Electronic Publication: 2018 Sep 06.
DOI: 10.1016/j.clinph.2018.08.022
Abstrakt: Objectives: Periodic limb movements in sleep (PLMS) are thought to be prevalent in elderly populations, but their impact on quality of life remains unclear. We examined the prevalence of PLMS, impact of age on prevalence, and association between PLMS and sleepiness.
Methods: We identified limb movements in 2335 Wisconsin Sleep Cohort polysomnograms collected over 12 years. Prevalence of periodic limb movement index (PLMI) ≥15 was calculated at baseline (n = 1084). McNemar's test assessed changes in prevalence over time. Association of sleepiness and PLMS evaluated using linear mixed modeling and generalized estimating equations. Models adjusted for confounders.
Results: Prevalence of PLMI ≥15 at baseline was 25.3%. Longitudinal prevalence increased significantly with age (p = 2.97 × 10 -14 ). Sleepiness did not differ significantly between PLMI groups unless stratified by restless legs syndrome (RLS) symptoms. The RLS+/PLM+ group was sleepier than the RLS+/PLM- group. Multiple Sleep Latency Test trended towards increased alertness in the RLS-/PLM+ group compared to RLS-/PLM-.
Conclusions: A significant number of adults have PLMS and prevalence increased with age. No noteworthy association between PLMI category and sleepiness unless stratified by RLS symptoms.
Significance: Our results indicate that RLS and PLMS may have distinct clinical consequences and interactions that can help guide treatment approach.
(Copyright © 2018. Published by Elsevier B.V.)
Databáze: MEDLINE
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