Impact of HIV Infection on the Clinical Presentation and Survival of Non-Hodgkin Lymphoma: A Prospective Observational Study From Botswana.

Autor:	Milligan MG; Michael G. Milligan, Jeremy S. Abramson, Aliyah R. Sohani, Shahin Lockman, Bruce A. Chabner, and Scott L. Dryden-Peterson, Harvard Medical School; Elizabeth Bigger, Jeremy S. Abramson, and Aliyah R. Sohani, Massachusetts General Hospital; Shahin Lockman and Scott L. Dryden-Peterson, Brigham and Women's Hospital and Harvard T.H. Chan School of Public Health, Boston, MA; Michael G. Milligan, Elizabeth Bigger, Shahin Lockman, Bruce A. Chabner, and Scott L. Dryden-Peterson, Botswana Harvard AIDS Institute Partnership; Musimar Zola, Princess Marina Hospital; Mukendi K.A. Kayembe and Heluf Medhin, Botswana Ministry of Health, Gaborone, Botswana; and Gita Suneja, Duke University, Durham, NC., Bigger E; Michael G. Milligan, Jeremy S. Abramson, Aliyah R. Sohani, Shahin Lockman, Bruce A. Chabner, and Scott L. Dryden-Peterson, Harvard Medical School; Elizabeth Bigger, Jeremy S. Abramson, and Aliyah R. Sohani, Massachusetts General Hospital; Shahin Lockman and Scott L. Dryden-Peterson, Brigham and Women's Hospital and Harvard T.H. Chan School of Public Health, Boston, MA; Michael G. Milligan, Elizabeth Bigger, Shahin Lockman, Bruce A. Chabner, and Scott L. Dryden-Peterson, Botswana Harvard AIDS Institute Partnership; Musimar Zola, Princess Marina Hospital; Mukendi K.A. Kayembe and Heluf Medhin, Botswana Ministry of Health, Gaborone, Botswana; and Gita Suneja, Duke University, Durham, NC., Abramson JS; Michael G. Milligan, Jeremy S. Abramson, Aliyah R. Sohani, Shahin Lockman, Bruce A. Chabner, and Scott L. Dryden-Peterson, Harvard Medical School; Elizabeth Bigger, Jeremy S. Abramson, and Aliyah R. Sohani, Massachusetts General Hospital; Shahin Lockman and Scott L. Dryden-Peterson, Brigham and Women's Hospital and Harvard T.H. Chan School of Public Health, Boston, MA; Michael G. Milligan, Elizabeth Bigger, Shahin Lockman, Bruce A. Chabner, and Scott L. Dryden-Peterson, Botswana Harvard AIDS Institute Partnership; Musimar Zola, Princess Marina Hospital; Mukendi K.A. Kayembe and Heluf Medhin, Botswana Ministry of Health, Gaborone, Botswana; and Gita Suneja, Duke University, Durham, NC., Sohani AR; Michael G. Milligan, Jeremy S. Abramson, Aliyah R. Sohani, Shahin Lockman, Bruce A. Chabner, and Scott L. Dryden-Peterson, Harvard Medical School; Elizabeth Bigger, Jeremy S. Abramson, and Aliyah R. Sohani, Massachusetts General Hospital; Shahin Lockman and Scott L. Dryden-Peterson, Brigham and Women's Hospital and Harvard T.H. Chan School of Public Health, Boston, MA; Michael G. Milligan, Elizabeth Bigger, Shahin Lockman, Bruce A. Chabner, and Scott L. Dryden-Peterson, Botswana Harvard AIDS Institute Partnership; Musimar Zola, Princess Marina Hospital; Mukendi K.A. Kayembe and Heluf Medhin, Botswana Ministry of Health, Gaborone, Botswana; and Gita Suneja, Duke University, Durham, NC., Zola M; Michael G. Milligan, Jeremy S. Abramson, Aliyah R. Sohani, Shahin Lockman, Bruce A. Chabner, and Scott L. Dryden-Peterson, Harvard Medical School; Elizabeth Bigger, Jeremy S. Abramson, and Aliyah R. Sohani, Massachusetts General Hospital; Shahin Lockman and Scott L. Dryden-Peterson, Brigham and Women's Hospital and Harvard T.H. Chan School of Public Health, Boston, MA; Michael G. Milligan, Elizabeth Bigger, Shahin Lockman, Bruce A. Chabner, and Scott L. Dryden-Peterson, Botswana Harvard AIDS Institute Partnership; Musimar Zola, Princess Marina Hospital; Mukendi K.A. Kayembe and Heluf Medhin, Botswana Ministry of Health, Gaborone, Botswana; and Gita Suneja, Duke University, Durham, NC., Kayembe MKA; Michael G. Milligan, Jeremy S. Abramson, Aliyah R. Sohani, Shahin Lockman, Bruce A. Chabner, and Scott L. Dryden-Peterson, Harvard Medical School; Elizabeth Bigger, Jeremy S. Abramson, and Aliyah R. Sohani, Massachusetts General Hospital; Shahin Lockman and Scott L. Dryden-Peterson, Brigham and Women's Hospital and Harvard T.H. Chan School of Public Health, Boston, MA; Michael G. Milligan, Elizabeth Bigger, Shahin Lockman, Bruce A. Chabner, and Scott L. Dryden-Peterson, Botswana Harvard AIDS Institute Partnership; Musimar Zola, Princess Marina Hospital; Mukendi K.A. Kayembe and Heluf Medhin, Botswana Ministry of Health, Gaborone, Botswana; and Gita Suneja, Duke University, Durham, NC., Medhin H; Michael G. Milligan, Jeremy S. Abramson, Aliyah R. Sohani, Shahin Lockman, Bruce A. Chabner, and Scott L. Dryden-Peterson, Harvard Medical School; Elizabeth Bigger, Jeremy S. Abramson, and Aliyah R. Sohani, Massachusetts General Hospital; Shahin Lockman and Scott L. Dryden-Peterson, Brigham and Women's Hospital and Harvard T.H. Chan School of Public Health, Boston, MA; Michael G. Milligan, Elizabeth Bigger, Shahin Lockman, Bruce A. Chabner, and Scott L. Dryden-Peterson, Botswana Harvard AIDS Institute Partnership; Musimar Zola, Princess Marina Hospital; Mukendi K.A. Kayembe and Heluf Medhin, Botswana Ministry of Health, Gaborone, Botswana; and Gita Suneja, Duke University, Durham, NC., Suneja G; Michael G. Milligan, Jeremy S. Abramson, Aliyah R. Sohani, Shahin Lockman, Bruce A. Chabner, and Scott L. Dryden-Peterson, Harvard Medical School; Elizabeth Bigger, Jeremy S. Abramson, and Aliyah R. Sohani, Massachusetts General Hospital; Shahin Lockman and Scott L. Dryden-Peterson, Brigham and Women's Hospital and Harvard T.H. Chan School of Public Health, Boston, MA; Michael G. Milligan, Elizabeth Bigger, Shahin Lockman, Bruce A. Chabner, and Scott L. Dryden-Peterson, Botswana Harvard AIDS Institute Partnership; Musimar Zola, Princess Marina Hospital; Mukendi K.A. Kayembe and Heluf Medhin, Botswana Ministry of Health, Gaborone, Botswana; and Gita Suneja, Duke University, Durham, NC., Lockman S; Michael G. Milligan, Jeremy S. Abramson, Aliyah R. Sohani, Shahin Lockman, Bruce A. Chabner, and Scott L. Dryden-Peterson, Harvard Medical School; Elizabeth Bigger, Jeremy S. Abramson, and Aliyah R. Sohani, Massachusetts General Hospital; Shahin Lockman and Scott L. Dryden-Peterson, Brigham and Women's Hospital and Harvard T.H. Chan School of Public Health, Boston, MA; Michael G. Milligan, Elizabeth Bigger, Shahin Lockman, Bruce A. Chabner, and Scott L. Dryden-Peterson, Botswana Harvard AIDS Institute Partnership; Musimar Zola, Princess Marina Hospital; Mukendi K.A. Kayembe and Heluf Medhin, Botswana Ministry of Health, Gaborone, Botswana; and Gita Suneja, Duke University, Durham, NC., Chabner BA; Michael G. Milligan, Jeremy S. Abramson, Aliyah R. Sohani, Shahin Lockman, Bruce A. Chabner, and Scott L. Dryden-Peterson, Harvard Medical School; Elizabeth Bigger, Jeremy S. Abramson, and Aliyah R. Sohani, Massachusetts General Hospital; Shahin Lockman and Scott L. Dryden-Peterson, Brigham and Women's Hospital and Harvard T.H. Chan School of Public Health, Boston, MA; Michael G. Milligan, Elizabeth Bigger, Shahin Lockman, Bruce A. Chabner, and Scott L. Dryden-Peterson, Botswana Harvard AIDS Institute Partnership; Musimar Zola, Princess Marina Hospital; Mukendi K.A. Kayembe and Heluf Medhin, Botswana Ministry of Health, Gaborone, Botswana; and Gita Suneja, Duke University, Durham, NC., Dryden-Peterson SL; Michael G. Milligan, Jeremy S. Abramson, Aliyah R. Sohani, Shahin Lockman, Bruce A. Chabner, and Scott L. Dryden-Peterson, Harvard Medical School; Elizabeth Bigger, Jeremy S. Abramson, and Aliyah R. Sohani, Massachusetts General Hospital; Shahin Lockman and Scott L. Dryden-Peterson, Brigham and Women's Hospital and Harvard T.H. Chan School of Public Health, Boston, MA; Michael G. Milligan, Elizabeth Bigger, Shahin Lockman, Bruce A. Chabner, and Scott L. Dryden-Peterson, Botswana Harvard AIDS Institute Partnership; Musimar Zola, Princess Marina Hospital; Mukendi K.A. Kayembe and Heluf Medhin, Botswana Ministry of Health, Gaborone, Botswana; and Gita Suneja, Duke University, Durham, NC.
Jazyk:	angličtina
Zdroj:	Journal of global oncology [J Glob Oncol] 2018 Sep; Vol. 4, pp. 1-11.
DOI:	10.1200/JGO.17.00084
Abstrakt:	Purpose: Botswana has a high prevalence of HIV infection. Currently, there are few data regarding the sociodemographic factors, clinical characteristics, and outcomes of non-Hodgkin lymphoma (NHL)-an AIDS-defining cancer-in the country. Patients and Methods: This study used a prospective cancer registry to identify patients with a new diagnosis of NHL reporting for specialty cancer care at three hospitals in Botswana between October 2010 and August 2016. Treatment patterns and clinical outcomes were analyzed. Results: One hundred four patients with a new diagnosis of NHL were enrolled in this study, 72% of whom had HIV infection. Compared with patients not infected with HIV, patients infected with HIV were younger (median age, 53.9 v 39.1 years; P = .001) and more likely to present with an aggressive subtype of NHL (65.5% v 84.0%; P = .008). All patients infected with HIV received combined antiretroviral therapy throughout the course of the study, and similar chemotherapeutic regimens were recommended for all patients, regardless of subtype or HIV status (six to eight cycles of cyclophosphamide, doxorubicin, vincristine, and prednisone; or cyclophosphamide, doxorubicin, vincristine, and prednisone plus rituximab). There was no difference in 1-year mortality among patients not infected with HIV and patients infected with HIV (unadjusted analysis, 52.9% v 37.1%; hazard ratio [HR], 0.73; P = .33; adjusted analysis, HR, 0.57; P = .14). However, when compared with a cohort of patients in the United States matched by subtype, stage, age, sex, and race, patients in Botswana fared worse (1-year mortality, 22.8% v 46.3%; HR, 1.89; P = .001). Conclusion: Among patients with NHL reporting for specialty cancer care in Botswana, there is no association between HIV status and 1-year survival.
Databáze:	MEDLINE
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