Behavioral immune system activity predicts downregulation of chronic basal inflammation.

Autor: Gassen J; Department of Psychology, Texas Christian University, Fort Worth, Texas, United States of America., Prokosch ML; Department of Psychology, Tulane University, New Orleans, Louisiana, United States of America., Makhanova A; Department of Psychology, Florida State University, Tallahassee, Florida, United States of America., Eimerbrink MJ; Department of Psychology, Texas Christian University, Fort Worth, Texas, United States of America., White JD; Department of Psychology, Texas Christian University, Fort Worth, Texas, United States of America., Proffitt Leyva RP; Department of Psychology, Texas Christian University, Fort Worth, Texas, United States of America., Peterman JL; Department of Psychology, Texas Christian University, Fort Worth, Texas, United States of America., Nicolas SC; Department of Psychology, Texas Christian University, Fort Worth, Texas, United States of America., Reynolds TA; Department of Psychology, Florida State University, Tallahassee, Florida, United States of America., Maner JK; Department of Psychology, Florida State University, Tallahassee, Florida, United States of America., McNulty JK; Department of Psychology, Florida State University, Tallahassee, Florida, United States of America., Eckel LA; Department of Psychology, Florida State University, Tallahassee, Florida, United States of America., Nikonova L; Department of Psychology, Florida State University, Tallahassee, Florida, United States of America., Brinkworth JF; Department of Anthropology, University of Illinois at Urbana-Champaign, Champaign, IL, United States of America., Phillips MD; Department of Psychology, Texas Christian University, Fort Worth, Texas, United States of America., Mitchell JB; Department of Psychology, Texas Christian University, Fort Worth, Texas, United States of America., Boehm GW; Department of Psychology, Texas Christian University, Fort Worth, Texas, United States of America., Hill SE; Department of Psychology, Texas Christian University, Fort Worth, Texas, United States of America.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2018 Sep 20; Vol. 13 (9), pp. e0203961. Date of Electronic Publication: 2018 Sep 20 (Print Publication: 2018).
DOI: 10.1371/journal.pone.0203961
Abstrakt: Here, we present a mechanistically grounded theory detailing a novel function of the behavioral immune system (BIS), the psychological system that prompts pathogen avoidance behaviors. We propose that BIS activity allows the body to downregulate basal inflammation, preventing resultant oxidative damage to DNA and promoting longevity. Study 1 investigated the relationship between a trait measure of pathogen avoidance motivation and in vitro and in vivo proinflammatory cytokine production. Study 2 examined the relationship between this same predictor and DNA damage often associated with prolonged inflammation. Results revealed that greater trait pathogen avoidance motivation predicts a) lower levels of spontaneous (but not stimulated) proinflammatory cytokine release by peripheral blood mononuclear cells (PBMCs), b) lower plasma levels of the proinflammatory cytokine interleukin-6 (IL-6), and c) lower levels of oxidative DNA damage. Thus, the BIS may promote health by protecting the body from the deleterious effects of inflammation and oxidative stress.
Competing Interests: The authors have declared that no competing interests exist.
Databáze: MEDLINE
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