Pediatric Ventilator-Associated Events: Analysis of the Pediatric Ventilator-Associated Infection Data.

Autor:	Willson DF; Division of Pediatric Critical Care, Children's Hospital of Richmond at Virginia Commonwealth University, Richmond, VA., Hall M; Division of Pediatric Critical Care, Nationwide Children's Hospital, Columbus, OH., Beardsley A; Division of Pediatric Critical Care, Riley Hospital for Children at Indiana University Health, Indianapolis, IN., Hoot M; Division of Pediatric Critical Care, Children's Hospital of Richmond at Virginia Commonwealth University, Richmond, VA., Kirby A; Division of Pediatric Critical Care, Doernbecher Children's Hospital, Portland, OR., Hays S; Department of Statistical Sciences and Operations Research, Virginia Commonwealth University, Richmond, VA., Erickson S; Division of Pediatric Critical Care, Princess Margaret Hospital, Perth, WA, Australia., Truemper E; Division of Pediatric Critical Care, University of Nebraska Medical Center, Omaha, NE., Khemani R; Division of Pediatric Critical Care, Children's Hospital of Los Angeles, Los Angeles, CA.
Jazyk:	angličtina
Zdroj:	Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies [Pediatr Crit Care Med] 2018 Dec; Vol. 19 (12), pp. e631-e636.
DOI:	10.1097/PCC.0000000000001723
Abstrakt:	Objectives: To compare the prevalence of infection applying the proposed pediatric ventilator-associated events criteria versus clinician-diagnosed ventilator-associated infection to subjects in the pediatric ventilator-associated infection study. Design: Analysis of prospectively collected data from the pediatric ventilator-associated infection study. Setting: PICUs of 47 hospitals in the United States, Canada, and Australia. Patients: Two-hundred twenty-nine children ventilated for greater than 48 hours who had respiratory secretion cultures performed to evaluate for suspected ventilator-associated infection. Interventions: None. Measurements and Main Results: Applying the proposed pediatric ventilator-associated event criteria, 15 of 229 subjects in the ventilator-associated infection study qualified as "ventilator-associated condition" and five of 229 (2%) met criteria for "infection-related ventilator-associated complication." This was compared with 89 of 229 (39%) diagnosed as clinical ventilator-associated infection (Kappa = 0.068). Ten of 15 subjects identified as ventilator-associated condition did not meet criteria for infection-related ventilator-associated complication primarily because they did not receive 4 days of antibiotics. Ventilator-associated condition subjects were similar demographically to nonventilator-associated condition subjects and had similar mortality (13% vs 10%), PICU-free days (6.9 ± 7.7; interquartile range, 0-14 vs 9.8 ± 9.6; interquartile range, 0-19; p = 0.25), but fewer ventilator-free days (6.6 ± 9.3; interquartile range, 1-15 vs 12.4 ± 10.7; interquartile range, 0-22; p = 0.04). The clinical ventilator-associated infection diagnosis in the ventilator-associated infection study was associated with fewer PICU-free days but no difference in mortality or ventilator-free days. Conclusions: The ventilator-associated event criteria appear to be insensitive to the clinical diagnosis of ventilator-associated infection. Differentiation between ventilator-associated condition and infection-related ventilator-associated complication was primarily determined by the clinician decision to treat with antibiotics rather than clinical signs and symptoms. The utility of the proposed pediatric ventilator-associated event criteria as a surrogate for ventilator-associated infection criteria is unclear.
Databáze:	MEDLINE
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