Better than DEET Repellent Compounds Derived from Coconut Oil.

Autor: Zhu JJ; U.S. Department of Agriculture, Agricultural Research Service, Agroecosystem Management Research Unit, University of Nebraska, Lincoln, Nebraska, 68583, USA. jerry.zhu@ars.usda.gov., Cermak SC; U.S. Department of Agriculture, Agricultural Research Service, National Center for Agricultural Utilization Research, Peoria, Illinois, 61604, USA., Kenar JA; U.S. Department of Agriculture, Agricultural Research Service, National Center for Agricultural Utilization Research, Peoria, Illinois, 61604, USA., Brewer G; Department of Entomology, University of Nebraska, Lincoln, Nebraska, 68583, USA., Haynes KF; Department of Entomology, University of Kentucky, Lexington, 40546, USA., Boxler D; Department of Entomology, University of Nebraska, Lincoln, Nebraska, 68583, USA., Baker PD; Department of Entomology, University of Kentucky, Lexington, 40546, USA., Wang D; Key Laboratory of Bio-Pesticide Innovation and Application of Guangdong Province, Department of Entomology, College of Agriculture, South China Agricultural University, Guangzhou, 510642, Guangdong Province, China., Wang C; Department of Entomology, Rutgers University, New Brunswick, 08901, USA., Li AY; U.S. Department of Agriculture, Agricultural Research Service, Invasive Insect Biocontrol and Behavior Laboratory, Beltsville Agricultural Research Center-West, Beltsville, Maryland, 20705, USA., Xue RD; Anastasia Mosquito Control District, 120 EOC Drive, St. Augustine, Florida, 32092, USA., Shen Y; Anastasia Mosquito Control District, 120 EOC Drive, St. Augustine, Florida, 32092, USA., Wang F; Anastasia Mosquito Control District, 120 EOC Drive, St. Augustine, Florida, 32092, USA., Agramonte NM; U.S. Department of Agriculture, Agricultural Research Service, Center for Medical, Agricultural and Veterinary Entomology, Gainesville, Florida, 32608, USA., Bernier UR; U.S. Department of Agriculture, Agricultural Research Service, Center for Medical, Agricultural and Veterinary Entomology, Gainesville, Florida, 32608, USA., de Oliveira Filho JG; Departamento de Microbiologia, Imunologia, Parasitologia e Patologia, Instituto de Patologia Tropical e Saúde Pública, Universidade Federal de Goiás - UFG, Goiânia, GO, Brazil., Borges LMF; Departamento de Microbiologia, Imunologia, Parasitologia e Patologia, Instituto de Patologia Tropical e Saúde Pública, Universidade Federal de Goiás - UFG, Goiânia, GO, Brazil., Friesen K; U.S. Department of Agriculture, Agricultural Research Service, Agroecosystem Management Research Unit, University of Nebraska, Lincoln, Nebraska, 68583, USA., Taylor DB; U.S. Department of Agriculture, Agricultural Research Service, Agroecosystem Management Research Unit, University of Nebraska, Lincoln, Nebraska, 68583, USA.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2018 Sep 19; Vol. 8 (1), pp. 14053. Date of Electronic Publication: 2018 Sep 19.
DOI: 10.1038/s41598-018-32373-7
Abstrakt: Hematophagous arthropods are capable of transmitting human and animal pathogens worldwide. Vector-borne diseases account for 17% of all infectious diseases resulting in 700,000 human deaths annually. Repellents are a primary tool for reducing the impact of biting arthropods on humans and animals. N,N-Diethyl-meta-toluamide (DEET), the most effective and long-lasting repellent currently available commercially, has long been considered the gold standard in insect repellents, but with reported human health issues, particularly for infants and pregnant women. In the present study, we report fatty acids derived from coconut oil which are novel, inexpensive and highly efficacious repellant compounds. These coconut fatty acids are active against a broad array of blood-sucking arthropods including biting flies, ticks, bed bugs and mosquitoes. The medium-chain length fatty acids from C 8:0 to C 12:0 were found to exhibit the predominant repellent activity. In laboratory bioassays, these fatty acids repelled biting flies and bed bugs for two weeks after application, and ticks for one week. Repellency was stronger and with longer residual activity than that of DEET. In addition, repellency was also found against mosquitoes. An aqueous starch-based formulation containing natural coconut fatty acids was also prepared and shown to protect pastured cattle from biting flies up to 96-hours in the hot summer, which, to our knowledge, is the longest protection provided by a natural repellent product studied to date.
Databáze: MEDLINE
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