Long-term health and treatment outcomes in adult coeliac disease patients diagnosed by screening in childhood.

Autor: Kivelä L; Center for Child Health Research, University of Tampere and Tampere University Hospital, Tampere, Finland.; Department of Pediatrics, Hospital District of South Ostrobothnia, Seinäjoki, Finland., Popp A; Center for Child Health Research, University of Tampere and Tampere University Hospital, Tampere, Finland.; Institute for Mother and Child Health Bucharest, University of Medicine and Pharmacy 'Carol Davila', Bucharest, Romania., Arvola T; Center for Child Health Research, University of Tampere and Tampere University Hospital, Tampere, Finland.; Department of Pediatrics, Hospital District of Kanta-Häme, Hämeenlinna, Finland., Huhtala H; Faculty of Social Sciences, University of Tampere, Tampere, Finland., Kaukinen K; Department of Internal Medicine, Tampere University Hospital, Tampere, Finland.; Celiac Disease Research Center, University of Tampere, Tampere, Finland., Kurppa K; Center for Child Health Research, University of Tampere and Tampere University Hospital, Tampere, Finland.
Jazyk: angličtina
Zdroj: United European gastroenterology journal [United European Gastroenterol J] 2018 Aug; Vol. 6 (7), pp. 1022-1031. Date of Electronic Publication: 2018 May 17.
DOI: 10.1177/2050640618778386
Abstrakt: Background: The diagnostic yield of coeliac disease could be improved by screening in at-risk groups, but long-term benefits of this approach are obscure.
Objective: To investigate health, quality of life and dietary adherence in adult coeliac patients diagnosed in childhood by screening.
Methods: After thorough evaluation of medical history, follow-up questionnaires were sent to 559 adults with a childhood coeliac disease diagnosis. The results were compared between screen-detected and clinically-detected patients, and also between originally asymptomatic and symptomatic screen-detected patients.
Results: In total, 236 (42%) patients completed the questionnaires a median of 18.5 years after childhood diagnosis. Screen-detected patients ( n  = 48) had coeliac disease in the family and type 1 diabetes more often, and were less often smokers and members of coeliac societies compared to clinically-detected patients, whereas the groups did not differ in current self-experienced health or health concerns, quality of life or dietary adherence. Screen-detected, originally asymptomatic patients had more anxiety than those presenting with symptoms, whereas the subgroups were comparable in other current characteristics.
Conclusion: Comparable long-term outcomes between screen-detected and clinically-detected patients support risk-group screening for coeliac disease. However, asymptomatic patients may require special attention.
Databáze: MEDLINE
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