| Autor: |
Li ZX; College of Marine Life Sciences, Ocean University of China, Qingdao, Shandong 266003, China. zhaoxiali0503@163.com., Wang XF; Tobacco Research Institute, Chinese Academy of Agricultural Sciences, Qingdao, Shandong 266101, China. wangxiufang02@caas.cn., Ren GW; Tobacco Research Institute, Chinese Academy of Agricultural Sciences, Qingdao, Shandong 266101, China. renguangwei@caas.cn., Yuan XL; Tobacco Research Institute, Chinese Academy of Agricultural Sciences, Qingdao, Shandong 266101, China. rayrock@126.com., Deng N; Tobacco Research Institute, Chinese Academy of Agricultural Sciences, Qingdao, Shandong 266101, China. dnsmile0208@163.com., Ji GX; Tobacco Research Institute, Chinese Academy of Agricultural Sciences, Qingdao, Shandong 266101, China. 18853815579@163.com., Li W; College of Marine Life Sciences, Ocean University of China, Qingdao, Shandong 266003, China. liwei01@ouc.edu.cn., Zhang P; Tobacco Research Institute, Chinese Academy of Agricultural Sciences, Qingdao, Shandong 266101, China. zhangpeng@caas.cn. |
| Abstrakt: |
Considerable attention has been paid to marine derived endophytic fungi, owing to their capacity to produce novel secondary metabolites with potent bioactivities. In this study, two new compounds with a prenylated diphenyl ether structure-diorcinol L ( 1 ) and ( R )-diorcinol B ( 2 )-were isolated from the marine algal-derived endophytic fungus Aspergillus tennesseensis , along with seven known compounds: ( S )-diorcinol B ( 3 ), 9-acetyldiorcinol B ( 4 ), diorcinol C ( 5 ), diorcinol D ( 6 ), diorcinol E ( 7 ), diorcinol J ( 8 ), and a dihydrobenzofuran derivative 9 . Their structures were elucidated by extensive NMR spectroscopy studies. Compound 2 represents the first example of an R -configuration in the prenylated moiety. All these isolated compounds were examined for antimicrobial and cytotoxic activities. Compounds 1 ⁻ 9 exhibited antimicrobial activities against some human- and plant-pathogenic microbes with MIC values ranging from 2 to 64 μg/mL. Moreover, compound 9 displayed considerable inhibitory activity against the THP-1 cell line in vitro, with an IC 50 value of 7.0 μg/mL. |
