HLA-A, -B, -DRB1, -DQA1, and -DQB1 profile in a population from southern Brazil.

Autor: Reis PG; Laboratory of Immunogenetics, Department of Basic Health Sciences, State University of Maringá, Paraná, Brazil., Ambrosio-Albuquerque EP; Department of Biotechnology, Genetics, and Cell Biology, State University of Maringá, Paraná, Brazil., Fabreti-Oliveira RA; Institute of Medical Sciences, Faculty of Medical Sciences, Belo Horizonte, Minas Gerais, Brazil.; IMUNOLAB - Laboratory of Histocompatibility and Immunogenetic, Belo Horizonte, Minas Gerais, Brazil., Moliterno RA; Laboratory of Immunogenetics, Department of Basic Health Sciences, State University of Maringá, Paraná, Brazil., de Souza VH; Laboratory of Immunogenetics, Department of Basic Health Sciences, State University of Maringá, Paraná, Brazil., Sell AM; Laboratory of Immunogenetics, Department of Basic Health Sciences, State University of Maringá, Paraná, Brazil., Visentainer JEL; Laboratory of Immunogenetics, Department of Basic Health Sciences, State University of Maringá, Paraná, Brazil.
Jazyk: angličtina
Zdroj: HLA [HLA] 2018 Nov; Vol. 92 (5), pp. 298-303.
DOI: 10.1111/tan.13368
Abstrakt: The aim of this study was to determine the allele and haplotype frequencies of HLA-A, -B, -DRB1, and -DQB1 in a self-declared White population from the north and northwestern state of Paraná, southern Brazil, and compare the data with populations worldwide. The genotyping was performed with a group of 641 individuals, based on PCR-SSO and -SSP methods, and allele and haplotype frequencies were estimated. Comparisons with European, African, Asian, and Amerindian populations were performed. The most frequent allelic groups, alleles and haplotypes were: HLA-A*02, HLA-B*35, HLA-DRB1*07:01, HLA-DQB1*03:01, and HLA-A*01/B*08/DRB1*03:01. The results reinforced a predominance of a European composition in the self-declared White population from the north and northwestern Paraná.
(© 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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