Analysis of the Association of TNF -238G>A Gene Polymorphism with the Risk of Rheumatoid Arthritis Development in Russian Population in the Republic of Karelia.

Autor: Malysheva IE; Laboratory of Genetics, Institute of Biology, Karelian Research Center of the Russian Academy of Sciences, Petrozavodsk, Republic of Karelia, Russia. ie.malysheva@yandex.ru., Topchieva LV; Laboratory of Genetics, Institute of Biology, Karelian Research Center of the Russian Academy of Sciences, Petrozavodsk, Republic of Karelia, Russia., Balan OV; Laboratory of Genetics, Institute of Biology, Karelian Research Center of the Russian Academy of Sciences, Petrozavodsk, Republic of Karelia, Russia., Marusenko IM; Department of Hospital Therapy, Petrozavodsk State University, Petrozavodsk, Republic of Karelia, Russia., Barysheva OY; Department of Hospital Therapy, Petrozavodsk State University, Petrozavodsk, Republic of Karelia, Russia., Kurbatova IV; Laboratory of Genetics, Institute of Biology, Karelian Research Center of the Russian Academy of Sciences, Petrozavodsk, Republic of Karelia, Russia.
Jazyk: angličtina
Zdroj: Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2018 Sep; Vol. 165 (5), pp. 674-677. Date of Electronic Publication: 2018 Sep 17.
DOI: 10.1007/s10517-018-4239-y
Abstrakt: We studied association of the TNF gene -238G>A polymorphism (rs361525) with the risk of rheumatoid arthritis development in the Russian population living in the Republic of Karelia. The influence of rs361525 on the development of rheumatoid arthritis was revealed: genetic predisposition to this disease is associated with the presence of GG genotype. The effect of the genotype on the polymorphic locus of -238G>A on TNF mRNA content was revealed. Increased content of transcripts of this gene is associated with the presence of A allele.
Databáze: MEDLINE
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