Alleviating mechanical constraints to ventilation with heliox improves exercise endurance in adult survivors of very preterm birth.
| Autor: | Duke JW; Department of Biological Sciences, Northern Arizona University, Flagstaff, Arizona, USA., Zidron AM; Department of Pediatrics, Ohio University Heritage College of Osteopathic Medicine, Athens, Ohio, USA., Gladstone IM; Department of Pediatrics, Oregon Health & Science University, Portland, Oregon, USA., Lovering AT; Department of Human Physiology, University of Oregon, Eugene, Oregon, USA. |
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| Jazyk: | angličtina |
| Zdroj: | Thorax [Thorax] 2019 Mar; Vol. 74 (3), pp. 302-304. Date of Electronic Publication: 2018 Sep 14. |
| DOI: | 10.1136/thoraxjnl-2018-212346 |
| Abstrakt: | Adult survivors of very preterm birth (PRET) have significantly lower aerobic exercise capacities than their counterparts born at term (CONT), but the underlying cause is unknown. To test whether expiratory flow limitation (EFL) during exercise negatively affects exercise endurance in PRET, we had PRET and CONT exercise to exhaustion breathing air and again breathing heliox. In PRET, EFL decreased and time-to-exhaustion increased significantly while breathing heliox. Heliox had a minimal effect on EFL and had no effect on time-to-exhaustion in CONT. We conclude that aerobic exercise endurance in PRET is limited, in part, by mechanical ventilatory constraints, specifically EFL. Competing Interests: Competing interests: None declared. (© Author(s) (or their employer(s)) 2019. No commercial re-use. See rights and permissions. Published by BMJ.) |
| Databáze: | MEDLINE |
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