Association between itch and cancer in 16,925 patients with pruritus: Experience at a tertiary care center.

Autor: Larson VA; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland., Tang O; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland., Ständer S; Center for Chronic Pruritus, Department of Dermatology, University Hospital Münster, Münster, Germany., Kang S; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland., Kwatra SG; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland; Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland. Electronic address: skwatra1@jhmi.edu.
Jazyk: angličtina
Zdroj: Journal of the American Academy of Dermatology [J Am Acad Dermatol] 2019 Apr; Vol. 80 (4), pp. 931-937. Date of Electronic Publication: 2018 Sep 11.
DOI: 10.1016/j.jaad.2018.08.044
Abstrakt: Background: Pruritus has been associated with cancer. However, limited data are available on the types of underlying malignancies associated with pruritus.
Objective: We sought to characterize the association between pruritus and different cancer types, as well as variations by racial group.
Methods: Cross-sectional study of patients ≥18 years of age seen at the Johns Hopkins Health System during 2013-2017. Patients with pruritus were compared with patients without pruritus. Analyses were stratified by race.
Results: Patients with pruritus were more likely to have concomitant malignancy than those without pruritus (odds ratio 5.76, 95% confidence interval 5.53-6.00). Most strongly associated were cancers of the liver, gallbladder and biliary tract, hematopoietic system, and skin. Compared with white patients, black patients more frequently had soft tissue, dermatologic, and hematologic malignancies and less frequently had liver, respiratory, gastrointestinal, and gynecologic malignancies.
Limitations: The cross-sectional design precludes analysis of the temporal association between pruritus and malignancy. The study is limited to a single tertiary care center.
Conclusion: Pruritus is most strongly associated with cancers of the liver, skin, and hematopoietic system. Black patients with pruritus have a higher likelihood of skin, soft tissue, and hematologic malignancies than white patients, while whites have higher likelihoods of liver, respiratory, gastrointestinal, and gynecologic malignancies.
(Copyright © 2018 American Academy of Dermatology, Inc. Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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