| Autor: |
Austin KB, Bronzino J, Morgane PJ |
| Jazyk: |
angličtina |
| Zdroj: |
Brain research [Brain Res] 1986 Oct; Vol. 394 (2), pp. 267-73. |
| DOI: |
10.1016/0165-3806(86)90102-1 |
| Abstrakt: |
Long-term potentiation (LTP) was studied in the dentate gyrus of anesthetized normal and prenatally protein malnourished rats in adulthood. LTP was initiated by high-frequency stimulation of the perforant path. Potentiation of both population excitatory postsynaptic potential (EPSP) slope and population spike was studied at various times after conditioning out to 5 h. The results indicate that prenatal protein malnutrition has a differential effect on LTP. Although potentiation of the population spike was relatively unaffected, prenatal protein malnutrition did lead to a significant reduction in potentiation of the population EPSP. Several possibilities are proposed as to the cause of the differential effect. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
