Ventilatory and integrated physiological responses to chronic hypercapnia in goats.

Autor: Burgraff NJ; Department of Physiology, Medical College of Wisconsin, Milwaukee, WI, USA., Neumueller SE; Department of Physiology, Medical College of Wisconsin, Milwaukee, WI, USA., Buchholz K; Department of Physiology, Medical College of Wisconsin, Milwaukee, WI, USA., Langer TM 3rd; Department of Physiology, Medical College of Wisconsin, Milwaukee, WI, USA., Hodges MR; Department of Physiology, Medical College of Wisconsin, Milwaukee, WI, USA.; Neuroscience Research Center, Medical College of Wisconsin, Milwaukee, WI, USA., Pan L; Department of Physical Therapy, Marquette University, Milwaukee, WI, USA., Forster HV; Department of Physiology, Medical College of Wisconsin, Milwaukee, WI, USA.; Neuroscience Research Center, Medical College of Wisconsin, Milwaukee, WI, USA.; Zablocki Veterans Affairs Medical Center, Milwaukee, WI, 53226, USA.
Jazyk: angličtina
Zdroj: The Journal of physiology [J Physiol] 2018 Nov; Vol. 596 (22), pp. 5343-5363. Date of Electronic Publication: 2018 Oct 14.
DOI: 10.1113/JP276666
Abstrakt: Key Points: Chronic hypercapnia per se has distinct effects on the mechanisms regulating steady-state ventilation and the CO 2 /H + chemoreflex. Chronic hypercapnia leads to sustained hyperpnoea that exceeds predicted ventilation based upon the CO 2 /H + chemoreflex. There is an integrative ventilatory, cardiovascular and metabolic physiological response to chronic hypercapnia. Chronic hypercapnia leads to deterioration of cognitive function.
Abstract: Respiratory diseases such as chronic obstructive pulmonary disease (COPD) often lead to chronic hypercapnia which may exacerbate progression of the disease, increase risk of mortality and contribute to comorbidities such as cognitive dysfunction. Determining the contribution of hypercapnia per se to adaptations in ventilation and cognitive dysfunction within this patient population is complicated by the presence of multiple comorbidities. Herein, we sought to determine the role of chronic hypercapnia per se on the temporal pattern of ventilation and the ventilatory CO 2 /H + chemoreflex by exposing healthy goats to either room air or an elevated inspired CO 2 (InCO 2 ) of 6% for 30 days. A second objective was to determine whether chronic hypercapnia per se contributes to cognitive dysfunction. During 30 days of exposure to 6% InCO 2 , steady-state (SS) ventilation ( V ̇ I ) initially increased to 335% of control, and then within 1-5 days decreased and stabilized at ∼230% of control. There was an initial respiratory acidosis that was partially mitigated over time due to increased arterial [HCO 3 - ]. There was a transient decrease in the ventilatory CO 2 /H + chemoreflex, followed by return to pre-exposure levels. The SS V ̇ I during chronic hypercapnia was greater than predicted from the acute CO 2 /H + chemoreflex, suggesting separate mechanisms regulating SS V ̇ I and the chemoreflex. Finally, as assessed by a shape discrimination test, we found a sustained decrease in cognitive function during chronic hypercapnia. We conclude that chronic hypercapnia per se results in: (1) a disconnect between SS V ̇ I and the CO 2 /H + chemoreflex, and (2) deterioration of cognitive function.
(© 2018 The Authors. The Journal of Physiology © 2018 The Physiological Society.)
Databáze: MEDLINE
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