Burkitt lymphoma in Iraqi children: A distinctive form of sporadic disease with high incidence of EBV + cases and more frequent expression of MUM1/IRF4 protein in cases with head and neck presentation.

Autor: Uccini S; Istituto Pasteur Italia, Rome, Italy., Al-Jadiry MF; Children's Welfare Teaching Hospital, Baghdad College of Medicine, Baghdad, Iraq., Cippitelli C; Department of Clinical and Molecular Medicine, Pathology Unit, Sapienza University, Sant'Andrea Hospital, Rome, Italy., Talerico C; Department of Clinical and Molecular Medicine, Pathology Unit, Sapienza University, Sant'Andrea Hospital, Rome, Italy., Scarpino S; Department of Clinical and Molecular Medicine, Pathology Unit, Sapienza University, Sant'Andrea Hospital, Rome, Italy., Al-Darraji AF; Children's Welfare Teaching Hospital, Baghdad College of Medicine, Baghdad, Iraq., Al-Badri SAF; Children's Welfare Teaching Hospital, Baghdad College of Medicine, Baghdad, Iraq., Alsaadawi AR; Department of Pathology, Baghdad Medical City Complex, Baghdad, Iraq., Al-Hadad SA; Children's Welfare Teaching Hospital, Baghdad College of Medicine, Baghdad, Iraq., Ruco L; Department of Clinical and Molecular Medicine, Pathology Unit, Sapienza University, Sant'Andrea Hospital, Rome, Italy.
Jazyk: angličtina
Zdroj: Pediatric blood & cancer [Pediatr Blood Cancer] 2018 Dec; Vol. 65 (12), pp. e27399. Date of Electronic Publication: 2018 Sep 11.
DOI: 10.1002/pbc.27399
Abstrakt: Epstein-Barr virus (EBV)-related lymphoproliferative disorders are relatively common in Iraqi children. Burkitt lymphoma (BL) accounted for 40% of lymphoma cases. The mean age of 125 BL cases was 5.9 ± 3.1 years, and the male-to-female ratio was 3.6:1. Clinical presentation was abdominal in 66% and head and neck in 34%. Bone marrow involvement was higher (P < 0.001) in children with head and neck disease. Tumor cells had MYC translocation (96%) and were CD20 + /CD10 + /MYC + /BCL2 - . MUM1/IRF4 staining was expressed by a fraction of tumor cells in 19 of 125 cases (15%) and was more frequent (P < 0.007) in head and neck disease (12/42; 29%). EBV-encoded RNA was positive in 100 of 125 (80%) BL cases.
(© 2018 Wiley Periodicals, Inc.)
Databáze: MEDLINE
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